Electrochemical late-stage functionalization

Y Wang, S Dana, H Long, Y Xu, Y Li… - Chemical …, 2023 - ACS Publications
Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or
diversification of novel molecular entities with improved physicochemical or biological …

Advances on the merger of electrochemistry and transition metal catalysis for organic synthesis

CA Malapit, MB Prater, JR Cabrera-Pardo, M Li… - Chemical …, 2021 - ACS Publications
Synthetic organic electrosynthesis has grown in the past few decades by achieving many
valuable transformations for synthetic chemists. Although electrocatalysis has been popular …

Photons or electrons? A critical comparison of electrochemistry and photoredox catalysis for organic synthesis

NES Tay, D Lehnherr, T Rovis - Chemical reviews, 2021 - ACS Publications
Redox processes are at the heart of synthetic methods that rely on either electrochemistry or
photoredox catalysis, but how do electrochemistry and photoredox catalysis compare? Both …

A perspective on late-stage aromatic C–H bond functionalization

L Zhang, T Ritter - Journal of the American Chemical Society, 2022 - ACS Publications
Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward
approach to the efficient synthesis of functionalized complex molecules. However, C–H LSF …

Fluorinated pyrazoles: From synthesis to applications

PK Mykhailiuk - Chemical Reviews, 2020 - ACS Publications
Fluorinated pyrazoles play an important role in medicinal chemistry, drug discovery,
agrochemistry, coordination chemistry, and organometallic chemistry. Since the early 1990s …

Recent advances in minisci‐type reactions

RSJ Proctor, RJ Phipps - Angewandte Chemie International …, 2019 - Wiley Online Library
Reactions that involve the addition of carbon‐centered radicals to basic heteroarenes,
followed by formal hydrogen atom loss, have become widely known as Minisci‐type …

Synthetic organic electrochemical methods since 2000: on the verge of a renaissance

M Yan, Y Kawamata, PS Baran - Chemical Reviews, 2017 - ACS Publications
Electrochemistry represents one of the most intimate ways of interacting with molecules. This
review discusses advances in synthetic organic electrochemistry since 2000. Enabling …

Electrochemical strategies for C–H functionalization and C–N bond formation

MD Kärkäs - Chemical Society Reviews, 2018 - pubs.rsc.org
Conventional methods for carrying out carbon–hydrogen functionalization and carbon–
nitrogen bond formation are typically conducted at elevated temperatures, and rely on …

Organic semiconductor photocatalyst can bifunctionalize arenes and heteroarenes

I Ghosh, J Khamrai, A Savateev, N Shlapakov… - Science, 2019 - science.org
Photoexcited electron-hole pairs on a semiconductor surface can engage in redox reactions
with two different substrates. Similar to conventional electrosynthesis, the primary redox …

Electrocatalytic C–H Activation

N Sauermann, TH Meyer, Y Qiu, L Ackermann - Acs Catalysis, 2018 - ACS Publications
C–H activation has emerged as a transformative tool in molecular synthesis, but until
recently oxidative C–H activations have largely involved the use of stoichiometric amounts of …