Four grams of glucose circulates in the blood of a person weighing 70 kg. This glucose is
critical for normal function in many cell types. In accordance with the importance of these 4 g …

The carotid bodies (CB) are peripheral chemoreceptors that sense changes in arterial blood
O2, CO2, and pH levels. Hypoxia, hypercapnia, and acidosis activate the CB, which respond …

Carotid body glomus cells sense hypoxia through the inhibition of plasmalemmal K+
channels, which leads to Ca2+ influx and transmitter release. Although the mechanism of O2 …

Sleep disorders like obstructive sleep apnea syndrome, periodic limb movements in sleep
syndrome, insomnia and narcolepsy-cataplexy are all associated with an increased risk of …

Chemoreceptors in the carotid bodies sense arterial oxygen tension and regulate
respiration. Isolated carotid body glomus cells also sense glucose, and animal studies have …

Obstructive sleep apnea causes chronic intermittent hypoxia (IH) and is associated with
impaired glucose metabolism, but mechanisms are unknown. Carotid bodies orchestrate …

Today, and in the foreseeable future, an appropriate understanding of the biomedical effects
of potentially significant natural and anthropogenic air contaminants will require conducting …

Key points Hypoglycaemia is counteracted by release of hormones and an increase in
ventilation and CO2 sensitivity to restore blood glucose levels and prevent a fall in blood pH …

This study was aimed at assessing the role of carotid body function in neuroendocrine and
glucoregulatory responses to exercise. The carotid bodies and associated nerves were …

New Findings What is the central question of this study? Hyperoxia blunts hypoglycaemia
counterregulation in healthy adults. We hypothesized that this effect is mediated by the …