Acute lymphoblastic leukemia displays a distinct highly methylated genome
DNA methylation is tightly regulated during development and is stably maintained in healthy
cells. In contrast, cancer cells are commonly characterized by a global loss of DNA …
cells. In contrast, cancer cells are commonly characterized by a global loss of DNA …
Dynamic antagonism between key repressive pathways maintains the placental epigenome
DNA and Histone 3 Lysine 27 methylation typically function as repressive modifications and
operate within distinct genomic compartments. In mammals, the majority of the genome is …
operate within distinct genomic compartments. In mammals, the majority of the genome is …
mHapTk: a comprehensive toolkit for the analysis of DNA methylation haplotypes
Bisulfite sequencing remains the gold standard technique to detect DNA methylation profiles
at single-nucleotide resolution. The DNA methylation status of CpG sites on the same …
at single-nucleotide resolution. The DNA methylation status of CpG sites on the same …
Genome-wide single-molecule analysis of long-read DNA methylation reveals heterogeneous patterns at heterochromatin that reflect nucleosome organisation
High-throughput sequencing technology is central to our current understanding of the
human methylome. The vast majority of studies use chemical conversion to analyse bulk …
human methylome. The vast majority of studies use chemical conversion to analyse bulk …