The RET receptor tyrosine kinase is crucial for normal development but also contributes to
pathologies that reflect both the loss and the gain of RET function. Activation of RET occurs …

The bulk structure of biological membranes consists of a bilayer of amphipathic lipids.
According to the fluid mosaic model proposed by Singer and Nicholson, the …

Glioblastoma multiforme (GBM) is amongst the deadliest of human cancers, with a median
survival rate of just over one year following diagnosis. Characterized by rapid proliferation …

The GDNF family ligands (GFLs) signal through the canonical signaling receptor Ret and a
glycosyl-phosphatidylinositol-anchored co-receptor, GFRα. In recent years, signaling by …

Growing axons encounter multiple guidance cues, but it is unclear how separate signals are
resolved and integrated into coherent instructions for growth cone navigation. We report that …

Summary Herpes simplex virus-1 (HSV-1) establishes life-long latency in peripheral
neurons where productive replication is suppressed. While periodic reactivation results in …

Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal
together or independently to fulfill many important functions in the midbrain dopaminergic …

No therapy exists to slow down or prevent Parkinson's disease (PD), a debilitating
neurodegenerative disorder. Neurotrophic factors (NTFs) emerged as promising disease …

By screening a tissue microarray of invasive breast tumors, we have shown that the receptor
tyrosine kinase RET (REarranged during Transfection) and its coreceptor GFRα1 (GDNF …

Rearranged during transfection (RET) is the tyrosine kinase receptor that under normal
circumstances interacts with ligand at the cell surface and mediates various essential roles …