Cytokines are involved in intestinal homeostasis and pathological processes associated
with inflammatory bowel disease (IBD). The biological effects of cytokines, including several …

Eleven new fluorine-containing FDA-approved drugs have been profiled and details of their
discovery and preparation are discussed. Therapeutic areas include schizophrenia …

Plaque psoriasis is a common, chronic, systemic, immune-mediated inflammatory disease.
The Janus kinase-signal transducer and activator of transcription pathway plays a major role …

Inflammatory bowel disease (IBD) refers to a gamut of disorders that are characterized by
chronic intestinal inflammation, including ulcerative colitis (UC) and Crohn's disease (CD) …

Abstract Sphingosine-1-phosphate (S1P) is a bioactive lipid metabolite that exerts its actions
by engaging 5 G-protein-coupled receptors (S1PR1-S1PR5). S1P receptors are involved in …

Inflammatory gastrointestinal (GI) diseases and malignancies are associated with growing
morbidity and cancer-related mortality worldwide. GI tumor and inflammatory cells contain …

The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate
the intracellular signaling of cytokines in a wide spectrum of cellular processes. They …

Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus
characterized clinically by symptoms related to esophageal dysfunction and histologically by …

Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal
inflammation, which currently lacks safe and effective medicine. Some previous studies …

Janus kinase (JAK) inhibitors, also known as jakinibs, are third-generation oral small
molecules that have expanded the therapeutic options for the management of chronic …