More than 25 years after its discovery, the post-transcriptional gene regulation mechanism
termed RNAi is now transforming pharmaceutical development, proved by the recent FDA …

Leptomeningeal metastases (LM) are increasingly becoming recognized as a treatable, yet
generally incurable, complication of advanced cancer. As modern cancer therapeutics have …

Cancer cellular heterogeneity and therapy resistance arise substantially from metabolic and
transcriptional adaptations, but how these are interconnected is poorly understood. Here, we …

This study sought to elucidate the mechanisms underlying the impact of the interferon
signaling pathway on Ferroptosis in tumor cells and its correlation with CD8+ T cell …

Small nucleotide variants in non-coding regions of the genome can alter transcriptional
regulation, leading to changes in gene expression which can activate oncogenic gene …

Background Melanoma is a highly aggressive form of skin cancer with increasing incidence
and mortality rates. Chemotherapy, the primary treatment for melanoma, is limited by …

The advent of effective immunotherapy, specifically cytotoxic T-lymphocyte associated
protein 4 and programmed cell death 1 inhibitors, as well as targeted therapy including …

Leptomeningeal metastases (LM) are increasingly becoming recognized as a treatable, yet
generally incurable, complication of advanced cancer. As modern cancer therapeutics have …

Resistance to MAPK inhibitors (MAPKi), the main cause of relapse in BRAF-mutant
melanoma, is associated with the production of alternative BRAF mRNA isoforms (altBRAFs) …

The intricate cooperation between cancer cells and nontumor stromal cells within melanoma
microenvironment (MME) enables tumor progression and metastasis. We previously …