Protein kinases are key components in cellular signaling pathways as they carry out the
phosphorylation of proteins, primarily on Ser, Thr, and Tyr residues. The catalytic activity of …

ABSTRACT C-Myc overexpression is a common finding in pancreatic cancer and predicts
the aggressive behavior of cancer cells. It binds to the promoter of different genes, thereby …

Pancreatic cancer (PC) is the fourth most common cause of death among all cancers. Poor
prognosis of PC may be caused by a prevalence of cancer stem cells (CSCs). CSCs are a …

The ever-growing perception of cancer stem cells (CSCs) as a plastic state rather than a
hardwired defined entity has evolved our understanding of the functional and biological …

Lung adenocarcinoma is the most common form of lung cancer, accounting for 60% of non-
small cell lung cancer (NSCLC) cases in Asian patients. Importantly, nearly half of these …

Extracellular signal-regulated kinase 5 (ERK5) belongs to the mitogen-activated protein
kinase (MAPK) family that consists of highly conserved enzymes expressed in all eukaryotic …

Atherosclerosis is a chronic inflammatory disease with high morbidity and mortality rates
worldwide. Doublecortin‐like kinase 1 (DCLK1), a microtubule‐associated protein kinase, is …

Epithelial to mesenchymal transition (EMT) is a central regulatory program that is similar in
many aspects to several steps of embryonic morphogenesis. In addition to its physiological …

Background More than 80% of intestinal neoplasia is associated with the adenomatous
polyposis coli (APC) mutation. Doublecortin-like kinase 1 (Dclk1), a kinase protein, is …

Mitogen-activated protein kinases (MAP kinases) are a family of kinases that regulates a
range of biological processes implicated in the response to growth factors like latelet …