Hundreds of genetic loci increasing risk for neuropsychiatric disorders have recently been
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …

A genetic basis for autism spectrum disorder (ASD) is now well established, and with the
availability of high‐throughput microarray and sequencing platforms, major advances have …

Schizophrenia is a complex and multifactorial disorder generally diagnosed in young adults
at the time of the first psychotic episode of delusions and hallucinations. These positive …

BackgroundMost studies underline the contribution of heritable factors for psychiatric
disorders. However, heritability estimates depend on the population under study, diagnostic …

Schizophrenia was initially defined as “dementia praecox” by E. Kraepelin, which implies
progressive deterioration. However, recent studies have revealed that early effective …

Recent studies indicate that long interspersed nuclear element-1 (L1) are mobilized in the
genome of human neural progenitor cells and enhanced in Rett syndrome and ataxia …

In schizophrenia, brain-wide alterations have been identified at the molecular and cellular
levels, yet how these phenomena affect cortical circuit activity remains unclear. We studied …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder. Several genetic causes
of ASD have been identified and this has enabled researchers to construct mouse models …

Summary 22q11. 2 deletion syndrome is characterised by a well defined microdeletion that
is associated with a high risk of neuropsychiatric disorders, including intellectual disability …

Highlights•Pathogenic CNVs are shared among neurodevelopmental and neuropsychiatric
disorders.•Understanding epigenetic regulation provides important insights not only into …