Obesity is associated with many adverse health effects, such as an increased
cardiometabolic risk. Despite higher adiposity for a given BMI, premenopausal women are at …

During the past decade, skeletal muscle has been identified as a secretory organ.
Accordingly, we have suggested that cytokines and other peptides that are produced …

Skeletal muscle has recently been identified as an endocrine organ. It has, therefore, been
suggested that cytokines and other peptides that are produced, expressed, and released by …

The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

In the past, the role of physical activity as a life-style modulating factor has been considered
as that of a tool to balance energy intake. Although it is important to avoid obesity, physical …

Skeletal muscle is the largest organ in the body. Skeletal muscles are primarily
characterized by their mechanical activity required for posture, movement, and breathing …

Long-chain fatty acids and lipids serve a wide variety of functions in mammalian
homeostasis, particularly in the formation and dynamic properties of biological membranes …

AMP-activated protein kinase (AMPK) is a key sensor and regulator of intracellular and
whole-body energy metabolism. We have identified a thienopyridone family of AMPK …

It has become increasingly apparent that substrate metabolism is subject to gender-specific
regulation, and the aim of this review is to outline the available evidence of molecular …

In female mammals, mechanisms have been developed, throughout evolution, to integrate
environmental, nutritional and hormonal cues in order to guarantee reproduction in …