In recent years, investigations on molecular interaction mechanisms between food proteins
and ligands have attracted much interest. The interaction mechanisms can supply much …

The interplay between life sciences and advancing technology drives a continuous cycle of
chemical data growth; these data are most often stored in open or partially open databases …

Structural biology aims at characterizing the structural and dynamic properties of biological
macromolecules at atomic details. Gaining insight into three dimensional structures of …

In the past two decades, 7 coronaviruses have infected the human population, with two
major outbreaks caused by SARS-CoV and MERS-CoV in the year 2002 and 2012 …

Arachidonic and adrenic acids in the membrane play key roles in ferroptosis. Here, we
reveal that lipoprotein-associated phospholipase A2 (Lp-PLA2) controls intracellular …

The COVID-19 pandemic has spread rapidly and poses an unprecedented threat to the
global economy and human health. Broad-spectrum antivirals are currently being …

The use of remdesivir to treat COVID-19 will likely continue before clinical trials are
completed. Due to the lengthening pandemic and evolving nature of the virus, predicting …

The atrophic form of age-related macular degeneration (dry AMD) affects nearly 200 million
people worldwide. There is no Food and Drug Administration (FDA)-approved therapy for …

Abstract SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the
cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the …

Evolutionary and functional studies suggested that the emergence of the Omicron variants
can be determined by multiple fitness trade-offs including the immune escape, binding …