An increasing body of evidence highlights the strong potential for a diet rich in fruit and vegetables to delay, and often prevent, the onset of chronic diseases, including …
K Sikorska-Zimny, L Beneduce - Nutrients, 2021 - mdpi.com
Glucosinolates (GLS) and their derivatives are secondary plant metabolites abundant in Brassicaceae. Due to the enzymatic reaction between GLS and myrosinase enzyme …
X Xu, D Wang, C Zheng, B Gao, J Fan, P Cheng… - Theranostics, 2019 - ncbi.nlm.nih.gov
Progerin, a truncated unprocessed lamin A protein, causes tissue aging and degeneration. In this study we explored the role of progerin in the pathogenesis of intervertebral disc …
C Du, A Smith, M Avalos, S South, K Crabtree, W Wang… - Nutrients, 2019 - mdpi.com
Osteoarthritis (OA) is the most common joint disorder in the world and is the most frequent cause of walking related disability among older adults in the US, which brings a significant …
B Patel, GE Mann, SJ Chapple - Free Radical Biology and Medicine, 2018 - Elsevier
Diabetes and cardiometabolic disorders such as hypertension and obesity are major risk factors for the development of cardiovascular disease, with a wealth of evidence suggesting …
G Schulze-Tanzil - Journal of experimental pharmacology, 2021 - Taylor & Francis
Osteoarthritis (OA) therapy remains a large challenge since no causative treatment options are so far available. Despite some main pathways contributing to OA are identified its …
Sulforaphane, the native but unstable form of SFX-01, is an antioxidant that activates the NRF2 and inhibits the NF-KB pathways to achieve its actions. Resolving the mechanism (s) …
SJ Moon, J Jhun, J Ryu, JY Kwon, SY Kim, KA Jung… - PLoS …, 2021 - journals.plos.org
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an important transcription factor that plays a pivotal role in cellular defense against oxidative injury. Nrf2 signaling is involved in …
T Luo, X Fu, Y Liu, Y Ji, Z Shang - Molecules, 2021 - mdpi.com
Previous studies have demonstrated that sulforaphane (SFN) is a promising agent against osteoclastic bone destruction. However, the mechanism underlying its anti-osteoclastogenic …