ROR1-targeted delivery of miR-29b induces cell cycle arrest and therapeutic benefit in vivo in a CLL mouse model

CL Chiang, S Goswami, FW Frissora… - Blood, The Journal …, 2019 - ashpublications.org
Chronic lymphocytic leukemia (CLL) occurs in 2 major forms: aggressive and indolent. Low
miR-29b expression in aggressive CLL is associated with poor prognosis. Indiscriminate …

Identifying a novel ferroptosis-related prognostic score for predicting prognosis in chronic lymphocytic leukemia

B Pan, Y Li, Z Xu, Y Miao, H Yin, Y Kong… - Frontiers in …, 2022 - frontiersin.org
Background Chronic lymphocytic leukemia (CLL) is the most common leukemia in the
western world. Although the treatment landscape for CLL is rapidly evolving, there are still …

Genetic signature related to heme-hemoglobin metabolism pathway in sepsis secondary to pneumonia

GGF Leite, BP Scicluna, T van Der Poll… - NPJ systems biology …, 2019 - nature.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated
inflammatory response to pathogens. Bioinformatics and transcriptomics studies contribute …

PKCβ facilitates Leukemogenesis in Chronic Lymphocytic Leukaemia by promoting constitutive BCR-mediated signalling

J Hay, A Tarafdar, AK Holroyd, HA Moka, KM Dunn… - Cancers, 2022 - mdpi.com
Simple Summary Chronic lymphocytic leukaemia (CLL) is the most common blood cancer in
the Western world and remains incurable. While a cause for this cancer has not been …

Seven non-differentially expressed 'dark biomarkers' show transcriptional dysregulation in chronic lymphocytic leukemia

R Xin, X Feng, H Zhang, Y Wang, M Duan… - Personalized …, 2023 - Taylor & Francis
Aim: Transcriptional regulation is actively involved in the onset and progression of various
diseases. This study used the feature-engineering approach model-based quantitative …

蛋白激酶CβⅡ 通过IL-6 自分泌途径促进肝细胞癌侵袭的研究

刘敏, 陈添亮, 郭娟, 伊雪, 高洪泉, 巫佳翠… - 中国癌症 …, 2021 - china-oncology.com
背景与目的: 肿瘤微环境中存在的炎性因子参与肿瘤的生长及转移, 蛋白激酶CβⅡ (protein
kinase CβⅡ, PKCβⅡ) 能否通过调节炎性因子参与肝细胞癌(hepatocellular carcinoma, HCC) …

[PDF][PDF] Vedoucí práce: Mgr. Miroslav Boudný, Ph. D.

E BAJUSOVÁ - is.muni.cz
Hematologická malignita, chronická lymfocytární leukémie (CLL), je charakteri zována
akumulací zralých B lymfocytů. JAK/STAT signalizace je důležitá v patogenezi CLL …

Investigation of differentially expressed genes that contribute to therapeutic effects of bevacizumab in BRAF mutant melanoma

N Coupe - 2020 - ora.ox.ac.uk
Malignant melanoma is a highly aggressive and often lethal disease. In 2012, patient
outcomes were poor after resection of high-risk stage II and III melanoma, and vascular …

Protein kinase Cβ Ⅱ promotes invasion of hepatocellular carcinoma by modulating autocrine of IL-6

LIU Min, C Tianliang, GUO Juan, YI Xue… - China …, 2021 - china-oncology.com
Background and purpose: Multiple proinflammatory cytokines in tumorigenic
microenvironment are involved in the acquired capability for invasive growth and metastasis …

[图书][B] Characterization and Targeting of Different Stages of Malignant Cells in Chronic Lymphocytic Leukemia

CL Chiang - 2019 - search.proquest.com
Chronic lymphocytic leukemia (CLL) represents the most prevalent adult leukemia in
western countries with an accumulation of malignant, mature CD5+ CD19+ B-lymphocytes …