Lung antimicrobial proteins and peptides (AMPs) are major sentinels of innate immunity by
preventing microbial colonization and infection. Nevertheless bactericidal activity of AMPs …

Besides their primary involvement in the recycling and degradation of proteins in endo-
lysosomal compartments and also in specialized biological functions, cysteine cathepsins …

Amide surrogates are common in naturally occurring peptides and in synthetic peptides
used in therapy. Whereas backbone-engineered proteins are, to date, extremely laborious to …

Lung matrix homeostasis partly depends on the fine regulation of proteolytic activities. We
examined the expression of human cysteine cathepsins (Cats) and their relative contribution …

Background. Chronic obstructive pulmonary disease (COPD) is an irreversible disease
mainly caused by smoking. COPD is characterized by emphysema and chronic bronchitis …

Human cysteine cathepsins (family C1, clan CA) have long been regarded as ubiquitous
household enzymes, primarily involved in the recycling and degradation of proteins in …

Lung cysteine cathepsins B, K, L, and S contribute to physiological and pathological
processes including degradation of antimicrobial peptides/proteins (AMPs) such as …

Lung cysteine cathepsin S (CatS) that is a potent elastase plays a deleterious role in
alveolar remodeling during smoke-induced emphysema. Despite the presence of a reactive …

Human cysteine cathepsins (Cats) are implicated in lung injuries and tissue remodeling and
have recently emerged as important players in pulmonary inflammations. The proteolytic …

Human cystatin C (hCC), which has a pervasive distribution within body fluids and is
ubiquitously expressed by numerous cells and tissues, is a highly potent extracellular …