Due to the physiological and structural properties of the blood–brain barrier (BBB), the
delivery of drugs to the brain poses a unique challenge in patients with central nervous …

The protective properties of the blood–brain barrier (BBB) are conferred by the intricate
architecture of its endothelium coupled with multiple specific transport systems expressed on …

Gamma-aminobutyric acid (GABA) and glutamate are implicated in numerous
neuropsychiatric and substance abuse conditions, but their spectral overlap with other …

α-Asaronol from Acorus tatarinowii (known as “Shichangpu” in Traditional Chinese
medicine) has been proved to possess more efficient antiepileptic activity and lower toxicity …

Living with epilepsy, for the majority of patients, is a continuous cycle of careful monitoring
and attention to health. When coupled with pregnancy, safety becomes the primary focus …

This chapter includes the aspects of carbamazepine. The drug is synthesized by the use of
5H-dibenz [b, f] azepine and phosgene followed by subsequent reaction with ammonia …

Multiple sclerosis (MS) is the most common chronic neurological disease affecting young
adults. MS diagnosis is based on clinical characteristics and confirmed by examination of …

The new antiepileptic medications are prescribed for the treatment of patients with seizure
disorders since 17 years ago. Gabapentin (GBP) was approved on January 1994 as …

Background: Neurotic disturbances, anxiety, neurosis-like disorders, and stress situations
are widespread. Benzodiazepine tranquillizers have been found to be among the most …

The imbalance between the GABA-mediated inhibition and the glutamate-mediated
excitation is the primary pathological mechanism of epilepsy. GABAergic and glutamatergic …