Nanoprecipitation and the “Ouzo effect”: Application to drug delivery devices

E Lepeltier, C Bourgaux, P Couvreur - Advanced drug delivery reviews, 2014 - Elsevier
Biodegradable nanocarriers such as lipid-or polymer-based nanoparticles can be designed
to improve the efficacy and reduce the toxic side effects of drugs. Under appropriate …

One-component nanomedicine

H Su, JM Koo, H Cui - Journal of controlled release, 2015 - Elsevier
One-component nanomedicine (OCN) represents an emerging class of therapeutic
nanostructures that contain only one type of chemical substance. This one-component …

Nanomedicine to target multidrug resistant tumors

E Lepeltier, P Rijo, F Rizzolio, R Popovtzer… - Drug Resistance …, 2020 - Elsevier
Nanomedicine employs nanotechnologies to develop innovative applications, and more
specifically nano-objects in the field of human health, through exploitation of the physical …

Self-assembled lipid–prodrug nanoparticles

P Couvreur, S Lepetre-Mouelhi, E Garbayo… - Nature Reviews …, 2023 - nature.com
Nanomedicines suffer from poor drug loading and uncontrolled 'burst release'after
administration. Combining prodrug strategies with nanostructured carriers can help to …

High-throughput nanoscale liposome formation via electrohydrodynamic-based micromixer

L Trabzon, G Karimian, AR Khosroshahi, B Gül… - Physics of …, 2022 - pubs.aip.org
Liposomes are one of the most attractive particles in different industries, especially
pharmaceutical applications. The main reasons for such a desire for liposomes are …

Pep‐lipid cubosomes and vesicles compartmentalized by Micelles from self‐assembly of multiple neuroprotective building blocks including a large peptide hormone …

A Angelova, M Drechsler, VM Garamus… - …, 2019 - Wiley Online Library
Structural control over design and formation of self‐assembled nanomaterials for
neuroprotection and neuroregeneration is crucial for their application in nanomedicine. Here …

Enzymatic Synthesis of Aptamer-Polynucleotide Nanoparticles with High Anticancer Drug Loading for Targeted Delivery

S Deshpande, Y Yang, S Zauscher… - Biomacromolecules, 2023 - ACS Publications
We report a targeted prodrug delivery platform that can deliver a cytostatic nucleobase
analog with high drug loading. We chose fluorouracil (5FU), a drug used to treat various …

Supramolecular nucleoside-based gel: molecular dynamics simulation and characterization of its nanoarchitecture and self-assembly mechanism

MGF Angelerou, PWJM Frederix, M Wallace, B Yang… - Langmuir, 2018 - ACS Publications
Among the diversity of existing supramolecular hydrogels, nucleic acid-based hydrogels are
of particular interest for potential drug delivery and tissue engineering applications because …

PEGylated squalenoyl-gemcitabine nanoparticles for the treatment of glioblastoma

A Gaudin, E Song, AR King, JK Saucier-Sawyer… - Biomaterials, 2016 - Elsevier
New treatments for glioblastoma multiforme (GBM) are desperately needed, as GBM
prognosis remains poor, mainly due to treatment resistance, poor distribution of therapeutics …

Drug delivery's quest for polymers: Where are the frontiers?

HP Merkle - European Journal of Pharmaceutics and …, 2015 - Elsevier
Since the legendary 1964 article of Folkman and Long entitled “The use of silicone rubber
as a carrier for prolonged drug therapy” the role of polymers in controlled drug delivery has …