Mitochondria are intracellular organelles involved in energy production, cell metabolism and
cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism …

Background Cuproptosis is a newly discovered unique non-apoptotic programmed cell
death distinguished from known death mechanisms like ferroptosis, pyroptosis, and …

Objective Glioblastoma is one of the most common intracranial malignant tumors with an
unfavorable prognosis, and iron metabolism as well as ferroptosis are implicated in the …

Uveitis causes blindness and critical visual impairment in people of all ages, and retinal
microglia participate in uveitis progression. Unfortunately, effective treatment is deficient …

Background Patient-derived glioma stem-like cells (GSCs) have become the gold-standard
in neuro-oncological research; however, it remains to be established whether loss of in situ …

Oxidative stress is one of the hallmarks of cancer. Tumorigenesis and progression are
accompanied by elevated reactive oxygen species (ROS) levels and adaptive elevation of …

Oxidative stress is a state of imbalance between oxidation and antioxidation. Excessive ROS
levels are an important factor in tumor development. Damage stimulation and excessive …

Tumor-initiating cells (TICs) reprogram their metabolic features to meet their bioenergetic,
biosynthetic, and redox demands. Our previous study established a role for wild-type …

Glioma is the most common malignant intracranial tumor and exhibits diffuse metastasis and
a high recurrence rate. The invasive property of glioma results from cell detachment. Anoikis …

The heterogeneity of tumor microenvironment (TME) and existence of cancer stem cells
(CSCs) severely impede the therapeutic efficacy of current anti-tumor treatments, which is …