Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs

ÉM Fekete, EP Zorrilla - Frontiers in neuroendocrinology, 2007 - Elsevier
Urocortins, three paralogs of the stress-related peptide corticotropin-releasing factor (CRF)
found in bony fish, amphibians, birds, and mammals, have unique phylogenies …

Stress-related neuropeptides and addictive behaviors: beyond the usual suspects

JR Schank, AE Ryabinin, WJ Giardino, R Ciccocioppo… - Neuron, 2012 - cell.com
Addictive disorders are chronic, relapsing conditions that cause extensive disease burden.
Genetic factors partly account for susceptibility to addiction, but environmental factors such …

Direct innervation of GnRH neurons by metabolic-and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus

RL Leshan, GW Louis, YH Jo, CJ Rhodes… - Journal of …, 2009 - Soc Neuroscience
Leptin acts via its receptor (LepRb) on specific CNS neurons to signal the adequacy of long-
term energy stores, thereby permitting the expenditure of resources on energy-intensive …

Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2

JM Deussing, J Breu, C Kühne, M Kallnik… - Journal of …, 2010 - Soc Neuroscience
Urocortin 3 (UCN3) is strongly expressed in specific nuclei of the rodent brain, at sites
distinct from those expressing urocortin 1 and urocortin 2, the other endogenous ligands of …

Dendritic spine density of posterodorsal medial amygdala neurons can be affected by gonadectomy and sex steroid manipulations in adult rats: a Golgi study

J de Castilhos, CD Forti, M Achaval, AA Rasia-Filho - Brain research, 2008 - Elsevier
The posterodorsal medial amygdala (MePD) is a sex steroid-responsive area in the rat
brain. The dendritic spine density of Golgi-impregnated MePD neurons were studied in:(1) …

Urocortin3: local inducer of somatostatin release and bellwether of beta cell maturity

MF Flisher, D Shin, MO Huising - Peptides, 2022 - Elsevier
Abstract Urocortin 3 (UCN3) is a peptide hormone expressed in pancreatic islets of
Langerhans of both human alpha and human beta cells and solely in murine beta cells …

Urocortins: CRF's siblings and their potential role in anxiety, depression and alcohol drinking behavior

AE Ryabinin, MM Tsoory, T Kozicz, TE Thiele… - Alcohol, 2012 - Elsevier
It is widely accepted that stress, anxiety, depression and alcohol abuse-related disorders are
in large part controlled by corticotropin-releasing factor (CRF) receptors. However, evidence …

Preclinical evidence implicating corticotropin‐releasing factor signaling in ethanol consumption and neuroadaptation

TJ Phillips, C Reed, R Pastor - Genes, Brain and Behavior, 2015 - Wiley Online Library
The results of many studies support the influence of the corticotropin‐releasing factor (CRF)
system on ethanol (EtOH) consumption and EtOH‐induced neuroadaptations that are critical …

Morphological and functional features of the sex steroid-responsive posterodorsal medial amygdala of adult rats

AA Rasia-Filho, D Haas, AP de Oliveira… - Mini reviews in …, 2012 - ingentaconnect.com
The rat posterodorsal medial amygdala (MePD) expresses receptors for gonadal hormones
and integrates sex steroid-sensitive subcortical networks. Male-female differences are found …

Urocortins: actions in health and heart failure

MT Rademaker, AM Richards - Clinica Chimica Acta, 2017 - Elsevier
The urocortins (Ucns), endogenous peptides belonging to the corticotropin-releasing factor
(CRF) family, are increasingly recognized as having diverse and important multi-system …