[HTML][HTML] Engineered three-dimensional scaffolds for enhanced bone regeneration in osteonecrosis

T Zhu, Y Cui, M Zhang, D Zhao, G Liu, J Ding - Bioactive materials, 2020 - Elsevier
Osteonecrosis, which is typically induced by trauma, glucocorticoid abuse, or alcoholism, is
one of the most severe diseases in clinical orthopedics. Osteonecrosis often leads to joint …

[HTML][HTML] Bone defect animal models for testing efficacy of bone substitute biomaterials

Y Li, SK Chen, L Li, L Qin, XL Wang, YX Lai - Journal of orthopaedic …, 2015 - Elsevier
Large bone defects are serious complications that are most commonly caused by extensive
trauma, tumour, infection, or congenital musculoskeletal disorders. If nonunion occurs …

Porous composite scaffold incorporating osteogenic phytomolecule icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits

Y Lai, H Cao, X Wang, S Chen, M Zhang, N Wang… - Biomaterials, 2018 - Elsevier
Steroid-associated osteonecrosis (SAON) often requires surgical core decompression (CD)
in the early stage for removal of necrotic bone to facilitate repair where bone grafts are …

The efficacy and safety of core decompression for the treatment of femoral head necrosis: a systematic review and meta-analysis

K Hua, X Yang, J Feng, F Wang, L Yang… - Journal of orthopaedic …, 2019 - Springer
Background Core decompression (CD) is an important method for the treatment of
osteonecrosis of the femoral head (ONFH). Few articles investigate the influence of core …

Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model

LZ Zheng, JL Wang, JK Xu, XT Zhang, BY Liu, L Huang… - Biomaterials, 2020 - Elsevier
Magnesium (Mg)-based biometal attracts clinical applications due to its biodegradability and
beneficial biological effects on tissue regeneration, especially in orthopaedics, yet the …

[HTML][HTML] Biodegradable magnesium incorporated microspheres enable immunomodulation and spatiotemporal drug release for the treatment of osteonecrosis of the …

F Yang, C Xu, W Zhang, L Sun, G Feng, T Ning… - Composites Part B …, 2023 - Elsevier
Osteonecrosis of the femoral head (ONFH) is a progressive disease that may lead to
collapse of the femoral head and subsequently, progression to osteoarthritis of the hip …

[HTML][HTML] Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments (an overview)

XH Xie, XL Wang, HL Yang, DW Zhao, L Qin - Journal of orthopaedic …, 2015 - Elsevier
Steroid-associated osteonecrosis (SAON) is a common orthopaedic problem caused by
administration of corticosteroids prescribed for many nonorthopaedic medical conditions …

Oxidative stress induced osteocyte apoptosis in steroid‐induced femoral head necrosis

ZQ Fan, SC Bai, Q Xu, ZJ Li, WH Cui, H Li… - Orthopaedic …, 2021 - Wiley Online Library
Objective To investigate the effect and mechanism of Glucocorticoids (GCs) induced
oxidative stress and apoptosis on necrosis of the femoral head in patients and rats. Methods …

The effects of a functionally-graded scaffold and bone marrow-derived mononuclear cells on steroid-induced femoral head osteonecrosis

M Maruyama, A Nabeshima, CC Pan, AW Behn, T Thio… - Biomaterials, 2018 - Elsevier
Osteonecrosis of the femoral head (ONFH) is a debilitating disease that may progress to
femoral head collapse and subsequently, degenerative arthritis. Although injection of bone …

[HTML][HTML] Advances in experimental models of osteonecrosis of the femoral head

Z Li, W Shao, X Lv, B Wang, L Han, S Gong… - Journal of Orthopaedic …, 2023 - Elsevier
Background Osteonecrosis of the femoral head (ONFH) is a devastating disease affecting
young adults, resulting in significant pain, articular surface collapse, and disabling …