It has been known for over a century that the basic organization of the retina is conserved
across vertebrates. It has been equally clear that retinal cells can be classified into …

Because the central nervous system is largely nonrenewing, neurons and their synapses
must be maintained over the lifetime of an individual to ensure circuit function. Age is a …

Mutations in the Membrane-type frizzled related protein (Mfrp) gene results in an early-onset
retinal degeneration associated with retinitis pigmentosa, microphthalmia, optic disc drusen …

Microglial cells are the key regulators of inflammation during retinal degeneration (RD) and
are conventionally classified as M1 or M2. However, whether the M1/M2 classification …

Uveitis, a complicated group of ocular inflammatory diseases, can be affected by massive
pathogenic contributors such as infection, autoimmunity, and genetics. Although it is well …

Microglia play important roles in maintaining homeostasis and immunoreactive defense in
the central nervous system including retina. To accomplish such a wide range of functions …

Purpose To investigate the potential relationship between subretinal microglia and
transplanted donor photoreceptors. Methods Photoreceptor precursors were transplanted …

Most forms of outer retinal degenerative diseases involve the ectopic accumulation of
microglia/macrophages in the subretinal space, including retinitis pigmentosa. However …

Purpose: Pigment epithelium-derived factor (PEDF) is a neurotrophic glycoprotein secreted
by the retinal pigment epithelium (RPE) that supports retinal photoreceptor health. Deficits in …

摘要干细胞治疗视网膜变性疾病的安全性和有效性得到大量实验证据的支持,
已进入临床研究阶段. 然而, 干细胞移植变性视网膜后, 治疗效果往往在后期出现消退甚至消失 …