Phosphoregulation of phase separation by the SARS-CoV-2 N protein suggests a biophysical basis for its dual functions
The nucleocapsid (N) protein of coronaviruses serves two major functions: compaction of the
RNA genome in the virion and regulation of viral gene transcription. It is not clear how the N …
RNA genome in the virion and regulation of viral gene transcription. It is not clear how the N …
[HTML][HTML] Repetitive RNAs as regulators of chromatin-associated subcompartment formation by phase separation
Repetitive RNA (repRNA) sequences emerge as important regulators of the dynamic
organization of genomic loci into membrane-less subcompartments with distinct nuclear …
organization of genomic loci into membrane-less subcompartments with distinct nuclear …
Nuclear phosphoinositides—Versatile regulators of genome functions
E Castano, S Yildirim, V Fáberová, A Krausová… - Cells, 2019 - mdpi.com
The many functions of phosphoinositides in cytosolic signaling were extensively studied;
however, their activities in the cell nucleus are much less clear. In this review, we summarize …
however, their activities in the cell nucleus are much less clear. In this review, we summarize …
Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation
Cells organize biochemical processes into biological condensates. P-bodies are
cytoplasmic condensates that are enriched in enzymes important for mRNA degradation and …
cytoplasmic condensates that are enriched in enzymes important for mRNA degradation and …
Condensation of LINE-1 is critical for retrotransposition
Abstract LINE-1 (L1) is the only autonomously active retrotransposon in the human genome,
and accounts for 17% of the human genome. The L1 mRNA encodes two proteins, ORF1p …
and accounts for 17% of the human genome. The L1 mRNA encodes two proteins, ORF1p …
Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells
Heterochromatin maintains genome integrity and function, and is organised into distinct
nuclear domains. Some of these domains are proposed to form by phase separation through …
nuclear domains. Some of these domains are proposed to form by phase separation through …
Phosphorylation modulates liquid-liquid phase separation of the SARS-CoV-2 N protein
The nucleocapsid (N) protein of coronaviruses serves two major functions: compaction of the
RNA genome in the virion and regulation of viral gene transcription in the infected cell–. The …
RNA genome in the virion and regulation of viral gene transcription in the infected cell–. The …
Histone H3 and H4 tails play an important role in nucleosome phase separation
EF Hammonds, MC Harwig, EA Paintsil, EA Tillison… - Biophysical …, 2022 - Elsevier
Chromatin organization and its dynamic regulation are crucial in governing the temporal and
spatial accessibility of DNA for proper gene expression. Disordered chains of nucleosomes …
spatial accessibility of DNA for proper gene expression. Disordered chains of nucleosomes …
[图书][B] Condensation of LINE-1 is required for retrotransposition
S Sil - 2022 - search.proquest.com
Retrotransposons are DNA sequences that are able to “copy and paste” themselves in the
genome using an RNA intermediate. LINE-1 (L1) is the only autonomously active …
genome using an RNA intermediate. LINE-1 (L1) is the only autonomously active …
Inhibition of SARS-CoV-2 nucleocapsid protein–RNA interaction by guanosine oligomeric RNA
R Sekine, S Tsuno, H Irokawa… - The Journal of …, 2023 - academic.oup.com
The interaction of the β-coronavirus severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) nucleocapsid (N) protein with genomic RNA is initiated by specific RNA …
(SARS-CoV-2) nucleocapsid (N) protein with genomic RNA is initiated by specific RNA …