Lyme disease Borrelia are obligately parasitic, tick-transmitted, invasive, persistent bacterial
pathogens that cause disease in humans and non-reservoir vertebrates primarily through …

Success in nature depends upon an ability to perceive and adapt to the surrounding
environment. Bacteria are not an exception; they recognize and constantly adjust to …

The identification of genes important in the pathogenesis of Lyme disease Borrelia has been
hampered by exceedingly low transformation rates in low-passage, infectious organisms …

Background. Controversy exists regarding the diagnosis and treatment of Lyme disease.
Patients with persistent symptoms after standard (2–4-week) antibiotic therapy for this …

Borrelia burgdorferi, the etiological agent of Lyme disease, exploits an array of strategies to
establish infection and to overcome host innate and adaptive immune responses. One key …

Heart diseases and related complications constitute a leading cause of death and
socioeconomic threat worldwide. Despite intense efforts and research on the pathogenetic …

Although Lyme disease remains a controversial illness, recent events have created an
unprecedented opportunity to make progress against this serious tick-borne infection …

The annual incidence of Lyme disease, caused by tick-transmitted Borreliella burgdorferi, is
estimated to be at least 476,000 cases in the United States and many more worldwide. Ten …

The Lyme disease spirochete controls production of its OspC and Erp outer surface proteins,
repressing protein synthesis during colonization of vector ticks but increasing expression …

The infectious cycle of Borrelia burgdorferi necessitates persistent infection of both
vertebrates and ticks, and efficient means of transmission between those two very different …