Investigations in the last 10 years have revealed a new category of neurological diseases
mediated by antibodies against cell surface and synaptic proteins. There are currently 16 …

Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by
cognitive dysfunction and synaptic failure. The current therapeutic approaches are mainly …

Objective To report the clinical and immunological features of a novel autoantigen related to
limbic encephalitis (LE) and the effect of patients' antibodies on neuronal cultures. Methods …

This introductory article to the special edition on glutamate neurotransmission in
neuropsychiatric disorders provides an overview of glutamate neurotransmitter system …

Even in healthy individuals there is an inexorable agerelated decline in cognitive function.
This is due, in large part, to reduced synaptic plasticity caused by changes in the molecular …

AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic
transmission in the brain. Diversity in excitatory signalling arises, in part, from functional …

CKAMP44, identified here by a proteomic approach, is a brain-specific type I
transmembrane protein that associates with AMPA receptors in synaptic spines. CKAMP44 …

Neurons are highly specialized cells whose connectivity at synapses subserves rapid
information transfer in the brain. Proper information processing, learning, and memory …

Glutamate-and GABA-releasing neurons form the basis for neurotransmission in the
mammalian central nervous system (CNS). The co-ordination of these excitatory and …

Glutamate, a nonessential amino acid, is a major bioenergetic substrate for proliferating
normal and neoplastic cells on one hand and an excitatory neurotransmitter that is actively …