Hybrid rhodamine fluorophores in the visible/NIR region for biological imaging
Fluorophores and probes are invaluable for the visualization of the location and dynamics of
gene expression, protein expression, and molecular interactions in complex living systems …
gene expression, protein expression, and molecular interactions in complex living systems …
Fluorescent probes for bioimaging of potential biomarkers in Parkinson's disease
Parkinson's disease (PD), as the second most common neurodegenerative disease, is
caused by complex pathological processes and currently remains very difficult to treat. PD …
caused by complex pathological processes and currently remains very difficult to treat. PD …
An endoperoxide reactivity-based FRET probe for ratiometric fluorescence imaging of labile iron pools in living cells
AT Aron, MO Loehr, J Bogena… - Journal of the American …, 2016 - ACS Publications
Iron is essential for sustaining life, as its ability to cycle between multiple oxidation states is
critical for catalyzing chemical transformations in biological systems. However, without …
critical for catalyzing chemical transformations in biological systems. However, without …
Two-photon small molecule enzymatic probes
Conspectus Enzymes are essential for life, especially in the development of disease and on
drug effects, but as we cannot yet directly observe the inside interactions and only partially …
drug effects, but as we cannot yet directly observe the inside interactions and only partially …
Current strategies for the development of fluorescence-based molecular probes for visualizing the enzymes and proteins associated with Alzheimer's disease
One of the most prevalent forms of dementia is Alzheimer's disease (AD) which causes
severe memory impairment within humans. As such, research into the early diagnosis of AD …
severe memory impairment within humans. As such, research into the early diagnosis of AD …
[HTML][HTML] Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives
Q Jin, JJ Wu, Y Wu, H Li, M Finel, D Wang… - Acta pharmaceutica sinica …, 2022 - Elsevier
Abstract Drug-metabolizing enzymes (DMEs), a diverse group of enzymes responsible for
the metabolic elimination of drugs and other xenobiotics, have been recognized as the …
the metabolic elimination of drugs and other xenobiotics, have been recognized as the …
Kinetics, mechanism, and inhibition of monoamine oxidase
Monoamine oxidases (MAOs) catalyse the oxidation of neurotransmitter amines and a wide
variety of primary, secondary and tertiary amine xenobiotics, including therapeutic drugs …
variety of primary, secondary and tertiary amine xenobiotics, including therapeutic drugs …
A small‐molecule probe for selective profiling and imaging of monoamine oxidase B activities in models of Parkinson's disease
The design of the first dual‐purpose activity‐based probe of monoamine oxidase B (MAO‐B)
is reported. This probe is highly selective towards MAO‐B, even at high MAO‐A expression …
is reported. This probe is highly selective towards MAO‐B, even at high MAO‐A expression …
Ratiometric near-infrared fluorescent probe for synergistic detection of monoamine oxidase B and its contribution to oxidative stress in cell and mice aging models
As new biomarkers, monoamine oxidases (MAOs) play important roles in maintaining the
homeostasis of biogenic amines via catalyzing the oxidation of biogenic amines to …
homeostasis of biogenic amines via catalyzing the oxidation of biogenic amines to …
Rapid two-photon fluorescence imaging of monoamine oxidase B for diagnosis of early-stage liver fibrosis in mice
Liver fibrosis could induce cirrhosis and liver cancer, causing serious damages to liver
function and even death. Early diagnosis of fibrosis is extremely requisite for optimizing …
function and even death. Early diagnosis of fibrosis is extremely requisite for optimizing …