The zebrafish heart as a model of mammalian cardiac function
CE Genge, E Lin, L Lee, XY Sheng, K Rayani… - Reviews of Physiology …, 2016 - Springer
Zebrafish (Danio rerio) are widely used as vertebrate model in developmental genetics and
functional genomics as well as in cardiac structure-function studies. The zebrafish heart has …
functional genomics as well as in cardiac structure-function studies. The zebrafish heart has …
Modeling inherited cardiomyopathies in adult zebrafish for precision medicine
Y Ding, H Bu, X Xu - Frontiers in Physiology, 2020 - frontiersin.org
Cardiomyopathies are a highly heterogeneous group of heart muscle disorders. More than
100 causative genes have been linked to various cardiomyopathies, which explain about …
100 causative genes have been linked to various cardiomyopathies, which explain about …
Zebrafish heart as a model to study the integrative autonomic control of pacemaker function
The cardiac pacemaker sets the heart's primary rate, with pacemaker discharge controlled
by the autonomic nervous system through intracardiac ganglia. A fundamental issue in …
by the autonomic nervous system through intracardiac ganglia. A fundamental issue in …
Phenotyping cardiomyopathy in adult zebrafish
AV Dvornikov, PP de Tombe, X Xu - Progress in biophysics and molecular …, 2018 - Elsevier
Hypertrophic cardiomyopathy (HCM) is usually manifested by increased myofilament Ca 2+
sensitivity, excessive contractility, and impaired relaxation. In contrast, dilated …
sensitivity, excessive contractility, and impaired relaxation. In contrast, dilated …
Phenotyping an adult zebrafish lamp2 cardiomyopathy model identifies mTOR inhibition as a candidate therapy
Adult zebrafish is an emerging vertebrate model for studying genetic basis of
cardiomyopathies; but whether the simple fish heart can model essential features of …
cardiomyopathies; but whether the simple fish heart can model essential features of …
Restrictive cardiomyopathy troponin I R145W mutation does not perturb myofilament length-dependent activation in human cardiac sarcomeres
The cardiac troponin I (cTnI) R145W mutation is associated with restrictive cardiomyopathy
(RCM). Recent evidence suggests that this mutation induces perturbed myofilament length …
(RCM). Recent evidence suggests that this mutation induces perturbed myofilament length …
A Langendorff-like system to quantify cardiac pump function in adult zebrafish
H Zhang, AV Dvornikov, IG Huttner… - Disease models & …, 2018 - journals.biologists.com
Zebrafish are increasingly used as a vertebrate model to study human cardiovascular
disorders. Although heart structure and function are readily visualized in zebrafish embryos …
disorders. Although heart structure and function are readily visualized in zebrafish embryos …
Fish, the better model in human heart research? Zebrafish heart aggregates as a 3D spontaneously cardiomyogenic in vitro model system
P Hodgson, J Ireland, B Grunow - Progress in biophysics and molecular …, 2018 - Elsevier
The zebrafish (ZF) has become an essential model for biomedical, pharmacological and eco-
toxicological heart research. Despite the anatomical differences between fish and human …
toxicological heart research. Despite the anatomical differences between fish and human …
Construction and use of a zebrafish heart voltage and calcium optical mapping system, with integrated electrocardiogram and programmable electrical stimulation
E Lin, C Craig, M Lamothe… - American Journal …, 2015 - journals.physiology.org
Zebrafish are increasingly being used as a model of vertebrate cardiology due to
mammalian-like cardiac properties in many respects. The size and fecundity of zebrafish …
mammalian-like cardiac properties in many respects. The size and fecundity of zebrafish …
Zebrafish as a model of mammalian cardiac function: optically mapping the interplay of temperature and rate on voltage and calcium dynamics
K Rayani, E Lin, C Craig, M Lamothe… - Progress in biophysics …, 2018 - Elsevier
The zebrafish (Danio rerio) heart is a viable model of mammalian cardiovascular function
due to similarities in heart rate, ultrastructure, and action potential morphology. Zebrafish are …
due to similarities in heart rate, ultrastructure, and action potential morphology. Zebrafish are …