Diabetes is a complex disease that affects over 400 million people worldwide. The life-long
insulin injections and continuous blood glucose monitoring required in type 1 diabetes …

Complex barriers separate immune-privileged tissues from the circulation. Here, we propose
that cell entry to immune-privileged sites through barriers composed of tight junction …

Corneal transplantation is the most successful solid organ transplantation performed in
humans. The extraordinary success of orthotopic corneal allografts, in both humans and …

Primary immune responses are initiated by dendritic cells (DCs), which inform naive T
helper (Th) cells about invading pathogens, providing an antigen-specific 'signal 1'and a …

Certain cellular components of the eye, such as neural retina, are unable to regenerate and
replicate after destructive inflammation. Ocular immune privilege provides the eye with …

The collapse of major histocompatiblity complex (MHC) class-I-dependent immune privilege
can lead to autoimmune disease or fetal rejection. Pragmatic and instructive models are …

It has been over 60 years since the phrase immune privilege was used by Sir Peter
Medawar to describe the lack of an immune response against allografts placed into the …

Simple Summary Survival after diagnosis of metastatic uveal melanoma has not significantly
improved over decades, most patients die within a year from diagnosis. Uveal melanoma is …

The importance of transforming growth factor-beta-1 (TGF-β1) in immunoregulation and
tolerance has been increasingly recognized. It is now proposed that there are populations of …

Intraocular inflammatory diseases are a common cause of severe visual impairment and
blindness. In this study, we investigated the immunoregulatory role of galectin-1 (Gal-1), an …