Exercise is the real polypill

C Fiuza-Luces, N Garatachea, NA Berger… - Physiology, 2013 - journals.physiology.org
The concept of a “polypill” is receiving growing attention to prevent cardiovascular disease.
Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free …

[HTML][HTML] Muscle as an endocrine organ: focus on muscle-derived interleukin-6

BK Pedersen, MA Febbraio - Physiological reviews, 2008 - journals.physiology.org
Skeletal muscle has recently been identified as an endocrine organ. It has, therefore, been
suggested that cytokines and other peptides that are produced, expressed, and released by …

Muscle as a secretory organ

BK Pedersen - Comprehensive physiology, 2011 - Wiley Online Library
Skeletal muscle is the largest organ in the body. Skeletal muscles are primarily
characterized by their mechanical activity required for posture, movement, and breathing …

Inflammatory processes in muscle injury and repair

JG Tidball - American Journal of Physiology-Regulatory …, 2005 - journals.physiology.org
Modified muscle use or injury can produce a stereotypic inflammatory response in which
neutrophils rapidly invade, followed by macrophages. This inflammatory response coincides …

[PDF][PDF] Interleukin-6 in acute exercise and training: what is the biological relevance?

CP Fischer - 2002 - eir-isei.de
It is now recognized that contracting skeletal muscle may synthesize and release interleukin-
6 (IL-6) into the interstitium as well as into the systemic circulation in response to a bout of …

Systemic inflammatory response to exhaustive exercise. Cytokine kinetics.

K Suzuki, S Nakaji, M Yamada, M Totsuka… - Exercise immunology …, 2002 - europepmc.org
It has been documented that strenuous exercise not only induces pyrogenesis but also
elicits mobilization and functional augmentation of neutrophils and monocytes whereas it …

[PDF][PDF] Characterization of inflammatory responses to eccentric exercise in humans

J Peake, KK Nosaka, K Suzuki - 2005 - ro.ecu.edu.au
Eccentric exercise commonly results in muscle damage. The primary sequence of events
leading to exercise-induced muscle damage is believed to involve initial mechanical …

Effects of resistance training on the inflammatory response

MC Calle, ML Fernandez - Nutrition research and practice, 2010 - synapse.koreamed.org
Resistance training (RT) is associated with reduced risk of low grade inflammation related
diseases, such as cardiovascular disease and type 2 diabetes. The majority of the data …

Delayed onset muscle soreness: Involvement of neurotrophic factors

K Mizumura, T Taguchi - The journal of physiological sciences, 2016 - Springer
Delayed-onset muscle soreness (DOMS) is quite a common consequence of unaccustomed
strenuous exercise, especially exercise containing eccentric contraction (lengthening …

[PDF][PDF] Exercise and cytokines with particular focus on muscle derived IL-6

BK Pedersen, A Steensberg, C Fischer… - Exercise immunology …, 2001 - researchgate.net
Exercise induces increased circulating levels of a number of cytokines. Thus, increased
plasma levels of tumour necrosis factor (TNF)-alpha interleukin (IL-1) beta, IL-1receptor …