Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

An epidemic of obesity has affected large portions of the world, increasing the risk of
developing many different age-associated diseases, including cancer, cardiovascular …

Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a
6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to …

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

Intermittent and periodic fasting (IF and PF, respectively) are emerging as safe strategies to
affect longevity and healthspan by acting on cellular aging and disease risk factors, while …

NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability,
mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+ …

Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

Excitotoxicity is one of the primary mechanisms of cell loss in a variety of diseases of the
central and peripheral nervous systems. Other than the previously established signaling …

Alzheimer's disease (AD) is one of the fastest growing cognitive decline-related neurological
diseases. To date, effective curative strategies have remained elusive. A growing body of …

NAD+, the essential metabolite involved in multiple reactions such as the regulation of
cellular metabolism, energy production, DNA repair, mitophagy and autophagy …