Metal-free multicomponent syntheses of pyridines

C Allais, JM Grassot, J Rodriguez… - Chemical …, 2014 - ACS Publications
They react according to a succession of mono-or bimolecular processes to form at the end
one product that incorporates important portions and functionalities of the starting materials …

Multicomponent reactions of ethyl trifluoroacetoacetate with carbonyl and nucleophilic reagents as a promising tool for organic synthesis

SO Kushch, MV Goryaeva, YV Burgart… - Russian Chemical …, 2023 - Springer
The review is summarized and systematized the published data on the multicomponent
reactions of ethyl trifluoroacetoacetate, carbonyl compounds (aldehydes and ketones), and …

Modular pyridine synthesis from oximes and enals through synergistic copper/iminium catalysis

Y Wei, N Yoshikai - Journal of the American Chemical Society, 2013 - ACS Publications
We describe here a [3+ 3]-type condensation reaction of O-acetyl ketoximes and α, β-
unsaturated aldehydes that is synergistically catalyzed by a copper (I) salt and a secondary …

Doubly stereoconvergent crystallization enabled by asymmetric catalysis

P de Jesús Cruz, WR Cassels, CH Chen, JS Johnson - Science, 2022 - science.org
Synthetic methods that enable simultaneous control over multiple stereogenic centers are
desirable for the efficient preparation of pharmaceutical compounds. Herein, we report the …

Synthesis of thioethers via metal-free reductive coupling of tosylhydrazones with thiols

Q Ding, B Cao, J Yuan, X Liu, Y Peng - Organic & Biomolecular …, 2011 - pubs.rsc.org
Synthesis of thioethers via metal-free reductive coupling of tosylhydrazones with thiols -
Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C0OB00639D Royal Society …

Metal-free synthesis of fully substituted pyridines via ring construction based on the domino reactions of enaminones and aldehydes

JP Wan, Y Jing, C Hu, S Sheng - The Journal of Organic …, 2016 - ACS Publications
An unprecedented domino reaction involving primary enaminones/enaminoesters and
aldehydes has been developed for the synthesis of fully substituted pyridines. The …

Visible-light-induced tandem radical addition–cyclization of alkenyl aldehydes leading to indanones and related compounds

D Lu, Y Wan, L Kong, G Zhu - Organic letters, 2017 - ACS Publications
Herein we describe a novel, visible light-induced tandem radical addition–cyclization of
alkenyl aldehydes with α-bromocarbonyl compounds. A set of cyclic ketones, including …

[HTML][HTML] Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines

BV Varun, K Vaithegi, S Yi, SB Park - Nature Communications, 2020 - nature.com
Despite the availability of numerous routes to substituted nicotinates based on the
Bohlmann–Rahtz pyridine synthesis, the existing methods have several limitations, such as …

N-Silylenamines as Reactive Intermediates: Hydroamination for the Modular Synthesis of Selectively Substituted Pyridines

EKJ Lui, D Hergesell, LL Schafer - Organic letters, 2018 - ACS Publications
A modular and selective synthesis of mono-, di-, tri-, tetra-, and pentasubstituted pyridines is
reported. Hydroamination of alkynes with N-silylamine using a bis (amidate) bis (amido) …

Nickel (II)-catalyzed C–C, N–C cascade coupling of ketonitriles into substituted pyrroles and pyridines

Q Zhen, R Li, L Qi, K Hu, X Yao, Y Shao… - Organic Chemistry …, 2020 - pubs.rsc.org
We have demonstrated the first ever example of nickel complexes as effective catalysts to
promote the C–C, N–C cascade coupling of ketonitriles with arylboronic acids, affording …