Opportunities and challenges for biosensors and nanoscale analytical tools for pandemics: COVID-19

N Bhalla, Y Pan, Z Yang, AF Payam - ACS nano, 2020 - ACS Publications
Biosensors and nanoscale analytical tools have shown huge growth in literature in the past
20 years, with a large number of reports on the topic of 'ultrasensitive','cost-effective', and …

RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic

L Tian, T Qiang, C Liang, X Ren, M Jia, J Zhang… - European journal of …, 2021 - Elsevier
The widespread nature of several viruses is greatly credited to their rapidly altering RNA
genomes that enable the infection to persist despite challenges presented by host cells …

An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles

H Li, Y Wu, M Li, L Guo, Y Gao, Q Wang… - Nature structural & …, 2023 - nature.com
Influenza polymerase (FluPol) transcribes viral mRNA at the beginning of the viral life cycle
and initiates genome replication after viral protein synthesis. However, it remains poorly …

Structural insights into RNA polymerases of negative-sense RNA viruses

AJW Te Velthuis, JM Grimes, E Fodor - Nature Reviews Microbiology, 2021 - nature.com
RNA viruses include many important human and animal pathogens, such as the influenza
viruses, respiratory syncytial virus, Ebola virus, measles virus and rabies virus. The …

Minimal Elements Required for the Formation of Respiratory Syncytial Virus Cytoplasmic Inclusion Bodies In Vivo and In Vitro

M Galloux, J Risso-Ballester, CA Richard, J Fix… - MBio, 2020 - Am Soc Microbiol
Infection of host cells by the respiratory syncytial virus (RSV) is characterized by the
formation of spherical cytoplasmic inclusion bodies (IBs). These structures, which …

Current state and challenges in respiratory syncytial virus drug discovery and development

G Zou, S Cao, Z Gao, J Yie, JZ Wu - Antiviral Research, 2024 - Elsevier
Human respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract
infections (LRTI) in young children and elderly people worldwide. Recent significant …

[HTML][HTML] Structures of the promoter-bound respiratory syncytial virus polymerase

D Cao, Y Gao, Z Chen, I Gooneratne, C Roesler… - Nature, 2024 - nature.com
The respiratory syncytial virus (RSV) polymerase is a multifunctional RNA-dependent RNA
polymerase composed of the large (L) protein and the phosphoprotein (P). It transcribes the …

Structure of the Newcastle Disease Virus L protein in complex with tetrameric phosphoprotein

J Cong, X Feng, H Kang, W Fu, L Wang… - Nature …, 2023 - nature.com
Newcastle disease virus (NDV) belongs to Paramyxoviridae, which contains lethal human
and animal pathogens. NDV RNA genome is replicated and transcribed by a multifunctional …

Structures of the Mononegavirales Polymerases

B Liang - Journal of Virology, 2020 - Am Soc Microbiol
Mononegavirales, known as nonsegmented negative-sense (NNS) RNA viruses, are a class
of pathogenic and sometimes deadly viruses that include rabies virus (RABV), human …

Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor

X Yu, P Abeywickrema, B Bonneux, I Behera… - Communications …, 2023 - nature.com
The respiratory syncytial virus polymerase complex, consisting of the polymerase (L) and
phosphoprotein (P), catalyzes nucleotide polymerization, cap addition, and cap methylation …