Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell
lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and …

Asthma is an inflammatory airway disease that is estimated to affect 339 million people
globally. The symptoms of about 5–10% of patients with asthma are not adequately …

We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …

Asthma exacerbations are among the most frequent causes of hospitalization during
childhood, but the underlying mechanisms are poorly understood. We performed a genome …

Atopic dermatitis often precedes the development of other atopic diseases. The atopic march
describes this temporal relationship in the natural history of atopic diseases. Although the …

Background Susceptibility to asthma is influenced by genes and environment; implicated
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful …

Background In mice, group 2 innate lymphoid cells (ILC2s) likely mediate helminth immunity,
inflammation, and tissue repair and remodeling. However, the involvement of ILC2s in …

Asthma and allergy are common conditions with complex etiologies involving both genetic
and environmental contributions. Recent genome‐wide association studies (GWAS) and …

Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …

The effects of drug dependence on social systems has helped shape the generally held
view that drug dependence is primarily a social problem, not a health problem. In turn …