Neutrophils have traditionally been viewed as bystanders or biomarkers of cardiovascular
disease. However, studies in the past decade have demonstrated the important functions of …

New evidence has challenged the outdated dogma that neutrophils are a homogeneous
population of short-lived cells. Although neutrophil subpopulations with distinct functions …

Inflammatory bowel diseases (IBD), comprising of ulcerative colitis and Crohn's disease, are
inflammatory disorders of the gastrointestinal tract characterized by chronically relapsing …

Neutrophils are versatile innate effector cells essential for immune defense but also
responsible for pathologic inflammation. This dual role complicates therapeutic targeting …

CD177 is a glycosylphosphatidylinositol (GPI)-anchored protein expressed by a variable
proportion of human neutrophils that mediates surface expression of the antineutrophil …

Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl
aminopeptidase. The best characterized physiological function of CatC is the activation of …

Neutrophils play essential anti-microbial and inflammatory roles in host defense, however,
their activities require tight regulation as dysfunction often leads to detrimental inflammatory …

Transfusion-related acute lung injury (TRALI) can occur during or after a transfusion, and
remains a leading cause of transfusion-associated morbidity and mortality. TRALI is caused …

Neutrophils are vital in defence against pathogens, but excessive neutrophil activity can
lead to tissue damage and promote acute respiratory distress syndrome. COVID-19 is …

Low Density Granulocytes (LDGs), which appear in the peripheral blood mononuclear cell
layer of density-separated blood, are seen in cancer, sepsis, autoimmunity, and pregnancy …