Visual impairment intracranial pressure (VIIP) syndrome is considered an unexplained
major risk for future long-duration spaceflight. NASA recently redefined this syndrome as …

Glaucoma and other optic neuropathies are characterized by progressive dysfunction and
loss of retinal ganglion cells and their axons. Given the high prevalence of glaucoma-related …

Purpose To propose a unifying theory regarding the pathogenesis of maculopathy
associated with cavitary optic disc anomalies and to describe a rational approach to …

This nontechnical review is focused upon educating the reader on optic nerve head
biomechanics in both aging and disease along two main themes: what is known about how …

Purpose To test the hypothesis that normal-tension glaucoma (NTG) is caused by an
increased pressure difference across the lamina cribrosa (LC) related to a low intracranial …

Amyloid-β (Aβ) accumulations have been identified in the retina for neurodegeneration-
associated disorders like Alzheimer's disease (AD), glaucoma, and age-related macular …

Purpose: The optic nerve (ON) sheath's role in limiting duction has been previously
unappreciated. This study employed magnetic resonance imaging (MRI) to demonstrate this …

The pathophysiology of primary open‐angle glaucoma is still largely unknown, although a
joint contribution of vascular, biomechanical, and biochemical factors is widely …

The underlying pathophysiology of primary open‐angle glaucoma remains unclear, but the
lamina cribrosa seems to be the primary site of injury, and raised intraocular pressure is a …

Ocular structural and functional changes, including optic disk edema and reduction of near
visual acuity, have been recently described in some astronauts returning from long-duration …