Gram-Negative Bacteria Holding Together in a Biofilm: The Acinetobacter baumannii Way

A Pompilio, D Scribano, M Sarshar, G Di Bonaventura… - Microorganisms, 2021 - mdpi.com
Bacterial biofilms are a serious public-health problem worldwide. In recent years, the rates of
antibiotic-resistant Gram-negative bacteria associated with biofilm-forming activity have …

The Intriguing Evolutionary Journey of Enteroinvasive E. coli (EIEC) toward Pathogenicity

M Pasqua, V Michelacci, ML Di Martino… - Frontiers in …, 2017 - frontiersin.org
Among the intestinal pathogenic Escherichia coli, enteroinvasive E. coli (EIEC) are a group
of intracellular pathogens able to enter epithelial cells of colon, multiplicate within them, and …

A bet-hedging strategy for denitrifying bacteria curtails their release of N2O

P Lycus, MJ Soriano-Laguna, M Kjos… - Proceedings of the …, 2018 - National Acad Sciences
When oxygen becomes limiting, denitrifying bacteria must prepare for anaerobic respiration
by synthesizing the reductases NAR (NO3−→ NO2−), NIR (NO2−→ NO), NOR (2NO→ …

ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens

M Proietti, L Perruzza, D Scribano, G Pellegrini… - Nature …, 2019 - nature.com
T cell dependent secretory IgA (SIgA) generated in the Peyer's patches (PPs) of the small
intestine shapes a broadly diverse microbiota that is crucial for host physiology. The …

Extracellular ATP as an inter-kingdom signaling molecule: release mechanisms by bacteria and its implication on the host

D Spari, G Beldi - International journal of molecular sciences, 2020 - mdpi.com
The purine adenosine 5′-triphosphate (ATP) is not only a universal intracellular energy
carrier but plays also an important role as extracellular signaling molecule. Purinergic …

T follicular helper cells promote a beneficial gut ecosystem for host metabolic homeostasis by sensing microbiota-derived extracellular ATP

L Perruzza, G Gargari, M Proietti, B Fosso, AM D'Erchia… - Cell reports, 2017 - cell.com
The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in
the Peyer's patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh …

Selection for phage resistance reduces virulence of Shigella flexneri

KE Kortright, RE Done, BK Chan, V Souza… - Applied and …, 2022 - Am Soc Microbiol
There is an increasing interest in phage therapy as an alternative to antibiotics for treating
bacterial infections, especially using phages that select for evolutionary trade-offs between …

Molecular mechanisms of Shigella effector proteins: a common pathogen among diarrheic pediatric population

A Nasser, M Mosadegh, T Azimi, A Shariati - Molecular and Cellular …, 2022 - Springer
Different gastrointestinal pathogens cause diarrhea which is a very common problem in
children aged under 5 years. Among bacterial pathogens, Shigella is one of the main …

Molecular and Cellular Mechanisms of Shigella flexneri Dissemination

H Agaisse - Frontiers in cellular and infection microbiology, 2016 - frontiersin.org
The intracellular pathogen Shigella flexneri is the causative agent of bacillary dysentery in
humans. The disease is characterized by bacterial invasion of intestinal cells, dissemination …

Update on molecular epidemiology of Shigella infection

IFN Lima, A Havt, AAM Lima - Current opinion in gastroenterology, 2015 - journals.lww.com
Knowledge about the epidemiologic profile of circulating serogroups of Shigella and an
understanding of its pathobiology as well as of the virulence genes is important for the …