The development of neoplasia involves a complex and continuous interplay between
malignantly transformed cells and the tumour microenvironment (TME). Cancer …

Colorectal cancer (CRC) is traditionally considered to be a genetically driven disease.
However, nongenetic plasticity has recently emerged as a major driver of tumour initiation …

Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet
these processes are often studied separately. To functionally map how cell-intrinsic and cell …

Patient-derived organoids (PDOs) can model personalized therapy responses; however,
current screening technologies cannot reveal drug response mechanisms or how tumor …

Mass cytometry (cytometry by time-of-flight detection [CyTOF]) is a bioanalytical technique
that enables the identification and quantification of diverse features of cellular systems with …

Realizing the translational impacts of three-dimensional (3D) bioprinting for cancer research
necessitates innovation in bioprinting workflows which integrate affordability, user …

Homeostatic functions of a living tissue, such as the gastrointestinal tract, rely on highly
sophisticated and finely tuned cell-to-cell interactions. These crosstalks evolve and …

Early diagnosis of hepatocellular carcinoma (HCC), a highly malignant disease, is crucial for
improving patient prognosis. Liquid biopsy has emerged as a promising approach for cancer …

Patient‐derived organoids have emerged as a useful tool to model tumour heterogeneity.
Scaling these complex culture models while enabling stratified analysis of different cellular …

Technical limitations have prevented understanding of how growth factor signals are
encoded in distinct activity patterns of the phosphoinositide 3-kinase (PI3K)/AKT pathway …