MicroRNAs (miRNAs) are small non-coding RNAs important in gene regulation. They are
able to regulate mRNA translation through base-pair complementarity. Cellular miRNAs …

Virologists have invested great effort into understanding how the herpes simplex viruses and
their relatives are maintained dormant over the lifespan of their host while maintaining the …

Reactivation of human cytomegalovirus (HCMV) is a significant cause of disease and death
in immunocompromised patients, underscoring the need to understand how latency is …

The identification of virally encoded microRNAs (miRNAs) has had a major impact on the
field of herpes virology. Given their ability to target cellular and viral transcripts, and the lack …

microRNAs are a class of small, single-stranded, noncoding RNAs that regulate gene
expression. They can be significantly dysregulated upon exposure to any infection, serving …

Herpesviruses are ubiquitous human pathogens. After productive (lytic) infection, all human
herpesviruses are able to establish life-long latent infection and reactivate from it. Latent …

The oral cavity incessantly encounters a plethora of microorganisms. Effective and efficient
oral innate and adaptive immune responses are incumbent to maintain healthy mucosa. A …

Intrinsic immunity is a first-line intracellular defense against virus infection, and viruses have
evolved mechanisms to counteract it. During herpes simplex virus (HSV) infection, nuclear …

Viral miRNAs,~ 22nt RNA molecules which post-transcriptionally regulate gene expression,
are emerging as important tools in immune evasion. Viral infection is a complex process that …

Several herpes simplex virus 1 microRNAs are encoded within or near the latency
associated transcript (LAT) locus, and are expressed abundantly during latency. Some of …