Recent progress in the drug development targeting SARS-CoV-2 main protease as treatment for COVID-19
W Cui, K Yang, H Yang - Frontiers in molecular biosciences, 2020 - frontiersin.org
The sudden outbreak of 2019 novel coronavirus (2019-nCoV, later named SARS-CoV-2)
rapidly turned into an unprecedented pandemic of coronavirus disease 2019 (COVID-19) …
rapidly turned into an unprecedented pandemic of coronavirus disease 2019 (COVID-19) …
The alpha keto amide moiety as a privileged motif in medicinal chemistry: current insights and emerging opportunities
M Robello, E Barresi, E Baglini, S Salerno… - Journal of Medicinal …, 2021 - ACS Publications
Over the years, researchers in drug discovery have taken advantage of the use of privileged
structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many …
structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many …
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19
DR Owen, CMN Allerton, AS Anderson… - Science, 2021 - science.org
The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral …
coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral …
α-Ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication: structure-based design, synthesis, and activity assessment
L Zhang, D Lin, Y Kusov, Y Nian, Q Ma… - Journal of medicinal …, 2020 - ACS Publications
The main protease of coronaviruses and the 3C protease of enteroviruses share a similar
active-site architecture and a unique requirement for glutamine in the P1 position of the …
active-site architecture and a unique requirement for glutamine in the P1 position of the …
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice
Pathogenic coronaviruses are a major threat to global public health, as exemplified by
severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory …
severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory …
Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19
Abstract The SARS-CoV-2 3CL protease is a critical drug target for small molecule COVID-
19 therapy, given its likely druggability and essentiality in the viral maturation and replication …
19 therapy, given its likely druggability and essentiality in the viral maturation and replication …
Reversal of the progression of fatal coronavirus infection in cats by a broad-spectrum coronavirus protease inhibitor
Y Kim, H Liu, AC Galasiti Kankanamalage… - PLoS …, 2016 - journals.plos.org
Coronaviruses infect animals and humans causing a wide range of diseases. The diversity
of coronaviruses in many mammalian species is contributed by relatively high mutation and …
of coronaviruses in many mammalian species is contributed by relatively high mutation and …
Design, synthesis, and biological evaluation of peptidomimetic aldehydes as broad-spectrum inhibitors against enterovirus and SARS-CoV-2
W Dai, D Jochmans, H Xie, H Yang, J Li… - Journal of medicinal …, 2021 - ACS Publications
A novel series of peptidomimetic aldehydes was designed and synthesized to target 3C
protease (3Cpro) of enterovirus 71 (EV71). Most of the compounds exhibited high antiviral …
protease (3Cpro) of enterovirus 71 (EV71). Most of the compounds exhibited high antiviral …
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal
Unprecedented efforts of the researchers have been witnessed in the recent past towards
the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit …
the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit …
Lopinavir; a potent drug against coronavirus infection: insight from molecular docking study
MR Dayer, S Taleb-Gassabi, MS Dayer - Archives of Clinical …, 2017 - brieflands.com
Background: The severe acute respiratory syndrome (SARS) is a life threatening viral
infection caused by a positive, single stranded RNA virus from the enveloped coronaviruse …
infection caused by a positive, single stranded RNA virus from the enveloped coronaviruse …