The recognition of DNA as an immune-stimulatory molecule is an evolutionarily conserved
mechanism to initiate rapid innate immune responses against microbial pathogens. The …

Significant research and preclinical investment in cancer nanomedicine has produced
several products, which have improved cancer care. Nevertheless, there exists a perception …

Indolent non-Hodgkin's lymphomas (iNHLs) are incurable with standard therapy and are
poorly responsive to checkpoint blockade. Although lymphoma cells are efficiently killed by …

Dendritic cells (DCs) mature in an immunogenic or tolerogenic manner depending on the
context in which an antigen is perceived, preserving the balance between immunity and …

Basal-like breast cancer exhibits a triple-negative phenotype and has a poor prognosis,
even with traditional chemical and anti-human epidermal growth factor receptor (HER) …

Minimally invasive thermal ablation of tumours has become common since the advent of
modern imaging. From the ablation of small, unresectable tumours to experimental …

Purpose: Checkpoint molecules like programmed death-1 (PD-1) and T-cell immunoglobulin
mucin-3 (TIM-3) are negative immune regulators that may be upregulated in the setting of …

The engulfment of apoptotic cells by phagocytes, a process referred to as efferocytosis, is
essential for maintenance of normal tissue homeostasis and a prerequisite for the resolution …

Cancer immunotherapy that deploys the host's immune system to recognize and attack
tumors, is a promising strategy for cancer treatment. However, its efficacy is greatly restricted …

Regulated necrosis, termed necroptosis, is negatively regulated by caspase-8 and is
dependent on the kinase activity of RIPK1 and RIPK3. Necroptosis leads to rapid plasma …