The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Prostate cancer (PCa) is the most common cancer in men. The androgen receptor (AR) has
a pivotal role in the pathogenesis and progression of PCa. Many therapies targeting AR …

Metastatic prostate cancer (PCa) inevitably acquires resistance to standard therapy
preceding lethality. Here, we unveil a chromosomal instability (CIN) tolerance mechanism as …

Cancer arises following alterations at different cellular levels, including genetic and
epigenetic modifications, transcription and translation dysregulation, as well as metabolic …

Hormones and receptors coevolve to generate species diversity in hormone action. We
compared the structure and function of androgen receptors (ARs) across fishes, with a focus …

Prostate cancer that recurs following androgen-deprivation therapy is termed castration-
resistant, which is incurable and is marked by reactivation of androgen receptor (AR) …

The constitutively active androgen receptor (AR) splice variant, AR-V7, plays an important
role in resistance to androgen deprivation therapy in castration resistant prostate cancer …

Androgen receptor (AR) is a nuclear hormone receptor that regulates the transcription of
genes involved in the development of testis, prostate and the nervous system. Misregulation …

Persistent androgen receptor (AR) signalling is the main driver of prostate cancer (PCa).
Truncated isoforms of the AR called androgen receptor variants (AR-Vs) lacking the ligand …

Currently, all clinically used androgen receptor (AR) antagonists target the AR ligand-
binding pocket and inhibit T and dihydrotestosterone (DHT) binding. Resistance to these …