Nanosystems for targeted drug Delivery: Innovations and challenges in overcoming the Blood-Brain barrier for neurodegenerative disease and cancer therapy

N Rafati, A Zarepour, A Bigham, A Khosravi… - International Journal of …, 2024 - Elsevier
The evolution of sophisticated nanosystems has revolutionized biomedicine, notably in
treating neurodegenerative diseases and cancer. These systems show potential in …

Modulation of engineered nanomaterial interactions with organ barriers for enhanced drug transport

V Lenders, X Koutsoumpou, P Phan… - Chemical Society …, 2023 - pubs.rsc.org
The biomedical use of nanoparticles (NPs) has been the focus of intense research for over a
decade. As most NPs are explored as carriers to alter the biodistribution, pharmacokinetics …

Ethanolic Extract Propolis-Loaded Niosomes Diminish Phospholipase B1, Biofilm Formation, and Intracellular Replication of Cryptococcus neoformans in …

K Kietrungruang, S Sookkree, S Sangboonruang… - Molecules, 2023 - mdpi.com
Secretory phospholipase B1 (PLB1) and biofilms act as microbial virulence factors and play
an important role in pulmonary cryptococcosis. This study aims to formulate the ethanolic …

Injectable controlled‐release systems for the prevention and treatment of infectious diseases

AA Kunkel, KJ McHugh - Journal of Biomedical Materials …, 2024 - Wiley Online Library
Pharmaceutical drugs, including vaccines, pre‐and post‐exposure prophylactics, and
chronic drug therapies, are crucial tools in the prevention and treatment of infectious …

Engineering advanced nanomedicines against central nervous system diseases

S Shi, H Ren, Y Xie, M Yu, Y Chen, L Yang - Materials Today, 2023 - Elsevier
Despite the impressive strides in the research community, numerous obstacles pose marked
challenges in the treatment of central nervous system (CNS) disorders. The limitations of …

From propolis to nanopropolis: An exemplary journey and a paradigm shift of a resinous substance produced by bees

S Javed, B Mangla, W Ahsan - Phytotherapy Research, 2022 - Wiley Online Library
Propolis, a natural resinous mixture produced by honey bees is poised with diverse
biological activities. Owing to the presence of flavonoids, phenolic acids, terpenes, and …

Critical Challenges of Intravenous Nanomaterials Crossing the Blood‐Brain Barrier: from Blood to Brain

W Luo, C Chen, X Guo, X Guo, J Zheng… - Advanced Functional …, 2024 - Wiley Online Library
Despite recent advancements in the development of blood‐brain barrier (BBB)‐crossing
nanomaterials for intravenous administration, there have been very few successful cases in …

Molecular Nanoparticles of Ferric–Tannic Complexes Enhance Brain Magnetic Resonance Imaging and Activate Brain Clearance Pathways

A Kittilukkana, T Phatruengdet, J Intakhad… - Analytical …, 2022 - ACS Publications
Iron-containing drugs can be considered beneficial for noninvasive magnetic resonance
imaging (MRI) and induction of essential biochemical processes. Herein, we present a new …

[HTML][HTML] Immunomodulation and Protective Effects of Cordyceps militaris Extract Against Candida albicans Infection in Galleria mellonella Larvae

K Eiamthaworn, D Holthaus, S Suriyaprom, V Rickerts… - Insects, 2024 - mdpi.com
Cordyceps militaris-derived formulations are currently used for multiple purposes because of
their medical properties, especially immune system modulation. This study analyzes the …

Sensitive bioluminescence imaging of cryptococcosis in Galleria mellonella improves antifungal screening under in vivo conditions

E Vanhoffelen, L Vermoesen, L Michiels, K Lagrou… - Virulence, 2024 - Taylor & Francis
Cryptococcus neoformans is an environmental yeast that primarily affects
immunocompromised individuals, causing respiratory infections and life-threatening …