Bacteria and their viruses have coevolved for billions of years. This ancient and still ongoing
arms race has led bacteria to develop a vast antiphage arsenal. The development of high …

The regulated disruption of the plasma membrane, which can promote cell death, cytokine
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …

The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

Bacteria have evolved diverse immunity mechanisms to protect themselves against the
constant onslaught of bacteriophages,–. Similar to how eukaryotic innate immune systems …

A fundamental strategy of eukaryotic antiviral immunity involves the cGAS enzyme, which
synthesizes 2′, 3′-cGAMP and activates the effector STING. Diverse bacteria contain …

Reverse transcription has frequently been co-opted for cellular functions and in prokaryotes
is associated with protection against viral infection, but the underlying mechanisms of …

Host defense against viral pathogens is an essential function for all living organisms. In cell-
intrinsic innate immunity, dedicated sensor proteins recognize molecular signatures of …

Highlights•Many antiphage systems trigger regulated death of the infected cell.•Regulated
cell death protects the nearby population from the spread of infection.•Over 70% of …

Cell-surface receptors play pivotal roles in many biological processes, including immunity,
development, and reproduction, across diverse organisms. How cell-surface receptors …

Plants coordinately use cell‐surface and intracellular immune receptors to perceive
pathogens and mount an immune response. Intracellular events of pathogen recognition are …