Approximately 70 human RNA-binding proteins (RBPs) contain a prion-like domain (PrLD).
PrLDs are low-complexity domains that possess a similar amino acid composition to prion …

Prions are self-templating protein conformers that are naturally transmitted between
individuals and promote phenotypic change. In yeast, prion-encoded phenotypes can be …

INTRODUCTION The formation of dynamic, membraneless compartments using intracellular
phase transitions such as phase separation and gelation provides an efficient way for cells …

In response to viral infection, RIG-I-like RNA helicases bind to viral RNA and activate the
mitochondrial protein MAVS, which in turn activates the transcription factors IRF3 and NF-κB …

Epigenetic signals are responsible for the establishment, maintenance, and reversal of
metastable transcriptional states that are fundamental for the cell's ability to “remember” past …

Many biologists are calling for an'extended evolutionary synthesis' that would'modernize the
modern synthesis' of evolution. Biological information is typically considered as being …

James A. Shapiro proposes an important new paradigm for understanding biological
evolution, the core organizing principle of biology. Shapiro introduces crucial new molecular …

The concept of a prion as an infectious self-propagating protein isoform was initially
proposed to explain certain mammalian diseases. It is now clear that yeast also has …

The Logic of Chance offers a reappraisal and a new synthesis of theories, concepts, and
hypotheses on the key aspects of the evolution of life on earth in light of comparative …

Abstract Changes in protein conformation can affect protein function, but methods to probe
these structural changes on a global scale in cells have been lacking. To enable large-scale …