Cancer is a global public health concern. Alterations in epigenetic processes are among the
earliest genomic aberrations occurring during cancer development and are closely related …

In June 2022, the FDA granted Accelerated Approval to the BRAF inhibitor dabrafenib in
combination with the MEK inhibitor trametinib for the treatment of adult and paediatric …

This ENETS guidance paper, developed by a multidisciplinary working group, provides up‐
to‐date and practical advice on the diagnosis and management of digestive neuroendocrine …

Neuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors
(NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for …

Poorly differentiated gastroenteropancreatic neuroendocrine carcinomas are aggressive
neoplasms of challenging clinical management. A small proportion of patients with early …

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Despite
significant progress that has been made in therapies against CRC over the past decades …

High-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are rare
but have a very poor prognosis and represent a severely understudied class of tumours …

Neuroendocrine neoplasms (NENs), which are characterized by neuroendocrine
differentiation, can arise in various organs. NENs have been divided into well-differentiated …

Poorly differentiated neuroendocrine carcinomas (PD-NEC) are rare cancers garnering
interest as they become more commonly encountered in the clinic. This is due to improved …

DNA methylation is a highly regulated process that has a critical role in human development
and homeostatic control of the cell. The number of genes affected by anomalous DNA …