Vitamin K is traditionally connected with blood coagulation, since it is needed for the
posttranslational modification of 7 proteins involved in this cascade. However, it is also …

In postmenopausal women and elderly men, bone density decreases with age and vascular
calcification is aggravated. This condition is closely associated with vitamin K2 deficiency. A …

Objective—Inhibition of mineral crystal formation is a crucial step in ectopic calcification.
Serum calciprotein particles (CPPs) have been linked to chronic kidney disease (CKD) …

Vitamin K is a fat-soluble vitamin that is indispensable for the activation of vitamin K-
dependent proteins (VKDPs) and may be implicated in cardiovascular disease (CVD) …

Chronic kidney disease (CKD) is one of the most powerful predictors of premature
cardiovascular disease (CVD), with heightened susceptibility to vascular intimal and medial …

Objective—Vascular and valvular calcifications are pathological processes regulated by
resident cells, and depending on a complex interplay between calcification promoters and …

Vitamin K-dependent (VKD) proteins undergo an unusual post-translational modification,
which is the conversion of specific Glu residues to carboxylated Glu (Gla). Gla generation is …

Calcification-related chronic inflammatory diseases are multifactorial pathological
processes, involving a complex interplay between inflammation and calcification events in a …

Calcium supplements are broadly prescribed to treat osteoporosis either as monotherapy or
together with vitamin D to enhance calcium absorption. It is still unclear whether calcium …

Osteoarthritis (OA) is a whole-joint disease characterized by articular cartilage loss, tissue
inflammation, abnormal bone formation and extracellular matrix (ECM) mineralization …