Uncovering protein networks in cardiovascular proteomics

M Hasman, M Mayr, K Theofilatos - Molecular & Cellular Proteomics, 2023 - ASBMB
Biological networks have been widely used in many different diseases to identify potential
biomarkers and design drug targets. In the present review, we describe the main …

IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy

L Pan, KS Cho, X Wei, F Xu, A Lennikov, G Hu, J Tang… - Cell reports, 2023 - cell.com
Microglia shift toward an inflammatory phenotype during aging that is thought to exacerbate
age-related neurodegeneration. The molecular and cellular signals that resolve …

Gene-by-environment modulation of lifespan and weight gain in the murine BXD family

S Roy, MB Sleiman, P Jha, JF Ingels, CJ Chapman… - Nature …, 2021 - nature.com
How lifespan and body weight vary as a function of diet and genetic differences is not well
understood. Here we quantify the impact of differences in diet on lifespan in a genetically …

Global gene expression and focused knockout analysis reveals genes associated with fungal fruiting body development in Neurospora crassa

Z Wang, F Lopez-Giraldez, N Lehr, M Farré… - Eukaryotic …, 2014 - Am Soc Microbiol
Fungi can serve as highly tractable models for understanding genetic basis of sexual
development in multicellular organisms. Applying a reverse-genetic approach to advance …

Using evolutionary genomics, transcriptomics, and systems biology to reveal gene networks underlying fungal development

Z Wang, A Gudibanda, U Ugwuowo, F Trail… - Fungal Biology …, 2018 - Elsevier
Fungal model species have contributed to many aspects of modern biology, from
biochemistry and cell biology to molecular genetics. Nevertheless, only a few genes …

Light sensing by opsins and fungal ecology: NOP‐1 modulates entry into sexual reproduction in response to environmental cues

Z Wang, J Wang, N Li, J Li, F Trail, JC Dunlap… - Molecular …, 2018 - Wiley Online Library
Understanding the genetic basis of the switch from asexual to sexual lifestyles in response
to sometimes rapid environmental changes is one of the major challenges in fungal ecology …

Pre‐transplant predictors of one yr weight gain after kidney transplantation

AK Cashion, DK Hathaway, A Stanfill… - Clinical …, 2014 - Wiley Online Library
Clinically useful predictors of weight gain could be used to reduce the epidemic of post‐
kidney transplant obesity and resulting co‐morbidities. The purpose of this study was to …

The ancestral levels of transcription and the evolution of sexual phenotypes in filamentous fungi

F Trail, Z Wang, K Stefanko, C Cubba… - PLoS genetics, 2017 - journals.plos.org
Changes in gene expression have been hypothesized to play an important role in the
evolution of divergent morphologies. To test this hypothesis in a model system, we …

Gun possession among American youth: A discovery-based approach to understand gun violence

KV Ruggles, S Rajan - PLoS One, 2014 - journals.plos.org
Objective To apply discovery-based computational methods to nationally representative
data from the Centers for Disease Control and Preventions' Youth Risk Behavior …

Genetic Dissection of the Regulatory Mechanisms of Ace2 in the Infected Mouse Lung

F Xu, J Gao, S Bergmann, AC Sims… - Frontiers in …, 2021 - frontiersin.org
Acute lung injury (ALI) is an important cause of morbidity and mortality after viral infections,
including influenza A virus H1N1, SARS-CoV, MERS-CoV, and SARS-CoV-2. The …