Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications
Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
Mitochondrial dysfunction in Parkinson's disease–a key disease hallmark with therapeutic potential
MT Henrich, WH Oertel, DJ Surmeier… - Molecular …, 2023 - Springer
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …
Mitochondrial calcium: effects of its imbalance in disease
D Matuz-Mares, M González-Andrade… - Antioxidants, 2022 - mdpi.com
Calcium is used in many cellular processes and is maintained within the cell as free calcium
at low concentrations (approximately 100 nM), compared with extracellular (millimolar) …
at low concentrations (approximately 100 nM), compared with extracellular (millimolar) …
[HTML][HTML] New insights into the complex role of mitochondria in Parkinson's disease
New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …
interactions as well as their role in cellular homeostasis have dramatically advanced our …
[HTML][HTML] Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and …
Reactive oxygen species (ROS) have been implicated in tumorigenesis (tumor initiation,
tumor progression, and metastasis). Of the many cellular sources of ROS generation, the …
tumor progression, and metastasis). Of the many cellular sources of ROS generation, the …
Kv1. 3 modulates neuroinflammation and neurodegeneration in Parkinson's disease
Characterization of the key cellular targets contributing to sustained microglial activation in
neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of …
neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of …
Mitochondrial dysfunction and Parkinson's disease: pathogenesis and therapeutic strategies
Parkinson's disease (PD) is a common age-related neurodegenerative disorder whose
pathogenesis is not completely understood. Mitochondrial dysfunction and increased …
pathogenesis is not completely understood. Mitochondrial dysfunction and increased …
Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture …
Quercetin, one of the major flavonoids in plants, has been recently reported to have
neuroprotective effects against neurodegenerative processes. However, since the molecular …
neuroprotective effects against neurodegenerative processes. However, since the molecular …
Glucocorticoid-driven mitochondrial damage stimulates Tau pathology
F Du, Q Yu, RH Swerdlow, CL Waites - Brain, 2023 - academic.oup.com
Prolonged exposure to glucocorticoids, the main stress hormones, damages the brain and is
a risk factor for depression and Alzheimer's disease. Two major drivers of glucocorticoid …
a risk factor for depression and Alzheimer's disease. Two major drivers of glucocorticoid …
Targeting mitochondrial impairment in Parkinson's disease: challenges and opportunities
The underlying pathophysiology of Parkinson's disease is complex, but mitochondrial
dysfunction has an established and prominent role. This is supported by an already large …
dysfunction has an established and prominent role. This is supported by an already large …