Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Ryanodine receptors (RyRs) are huge ion channels that are responsible for the release of
Ca 2+ from the sarco/endoplasmic reticulum. RyRs form homotetramers with a mushroom …

Regulation of intracellular calcium (Ca 2+) is critical in all cell types. The ryanodine receptor
(RyR), an intracellular Ca 2+ release channel located on the sarco/endoplasmic reticulum …

The cardiac ryanodine receptor (RyR) is the sarcoplasmic reticulum (SR) Ca-release
channel which is centrally involved in the myocyte excitation–contraction (E–C) coupling …

The small bilobal calcium regulatory protein calmodulin (CaM) activates numerous target
enzymes in response to transient changes in intracellular calcium concentrations. Binding of …

The endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR) form major intracellular
Ca 2+ stores. Ryanodine receptors (RyRs) are large tetrameric ion channels in the SR and …

Calmodulin (CaM) in complex with Ca 2+ channels constitutes a prototype for Ca 2+ sensors
that are intimately colocalized with Ca 2+ sources. The C-lobe of CaM senses local, large …

Calmodulin (CaM) is a ubiquitous Ca 2+-binding protein that regulates the ryanodine
receptors (RyRs) by direct binding. CaM inhibits the skeletal muscle ryanodine receptor …

Ca2+-dependent facilitation and inactivation (CDF and CDI) of Cav2. 1 channels modulate
presynaptic P/Q-type Ca2+ currents and contribute to activity-dependent synaptic plasticity …

Calmodulin (CaM) is an important intracellular protein that binds Ca2+ and functions as a
critical second messenger involved in numerous biological activities through extensive …