A marked decrease in malaria-related deaths worldwide has been attributed to the
administration of effective antimalarials against Plasmodium falciparum, in particular …

The artemisinin antimalarials are the cornerstone of current malaria treatment. The
development of artemisinin resistance in Plasmodium falciparum poses a major threat to …

The use of artemisinin-based combination therapies (ACTs), which combine an artemisinin
derivative with a partner drug, in the treatment of uncomplicated malaria has largely been …

Abstract In Southeast Asia, mutations in the Plasmodium falciparum K13 gene have led to
delayed parasite clearance and treatment failures in patients with malaria receiving …

Background Plasmodium falciparum infections with slow parasite clearance following
artemisinin-based therapies are widespread in the Greater Mekong Subregion. A molecular …

The emergence of artemisinin resistance is a major obstacle to the global malaria
eradication/elimination programs. Artemisinin is a very fast-acting antimalarial drug and is …

Background Malaria outbreaks are important public health concerns that can cause
resurgence in endemic regions approaching elimination. We investigated a Plasmodium …

Artemisinin resistance in Plasmodium falciparum is associated with nonsynonymous
mutations in the Kelch 13 (K13) propeller domain. We found that 12.1%(8/66) of clinical P …

Mutations in the Plasmodium falciparum Kelch 13 (PfK13) protein are associated with
artemisinin resistance. PfK13 is essential for asexual erythrocytic development, but its …

The global burden of malaria seems unabated. Africa carries the greatest burden accounting
for over 95% of the annual cases of malaria. For the vision of a world free of malaria by …