The biology and pathobiology of glutamatergic, cholinergic, and dopaminergic signaling in the aging brain

A Gasiorowska, M Wydrych, P Drapich… - Frontiers in aging …, 2021 - frontiersin.org
The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …

Current therapies in clinical trials of Parkinson's disease: A 2021 update

EM Prasad, SY Hung - Pharmaceuticals, 2021 - mdpi.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder that currently has no
cure, but treatments are available to improve PD symptoms and maintain quality of life. In …

Role of the cholinergic anti-inflammatory reflex in central nervous system diseases

IE Ramos-Martínez, MC Rodríguez, M Cerbón… - International Journal of …, 2021 - mdpi.com
In several central nervous system diseases, it has been reported that inflammation may be
related to the etiologic process, therefore, therapeutic strategies are being implemented to …

[HTML][HTML] Tricin promoted ATG-7 dependent autophagic degradation of α-synuclein and dopamine release for improving cognitive and motor deficits in Parkinson's …

X Wang, W Hu, L Qu, J Wang, A Wu, HH Lo… - Pharmacological …, 2023 - Elsevier
Tricin, a natural nontoxic flavonoid distributed in grasses and euphorbia plants, has been
reported to scavenge free radicals, possess anti-inflammatory and antioxidative effects …

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson's Disease

ÉN Soares, ACS Costa, GJ Ferrolho, RP Ureshino… - Cells, 2024 - mdpi.com
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by
resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor …

Novel pharmacotherapies in Parkinson's disease

Y Tizabi, B Getachew, M Aschner - Neurotoxicity Research, 2021 - Springer
Abstract Parkinson's disease (PD), an age-related progressive neurodegenerative condition,
is associated with loss of dopaminergic neurons in the substantia nigra pars compacta …

Understanding molecular signaling cascades in neural disease using multi-resolution models

NA Viswan, US Bhalla - Current opinion in neurobiology, 2023 - Elsevier
If the genome defines the program for the operations of a cell, signaling networks execute it.
These cascades of chemical, cell-biological, structural, and trafficking events span …

Search for safer and potent natural inhibitors of Parkinson's disease

ST Khan, S Ahmed, S Gul, A Khan… - Neurochemistry …, 2021 - Elsevier
Abstract After Alzheimer's disease, Parkinson's disease (PD) has taken second place in
becoming one of the most commonly occurring neurological diseases being responsible for …

Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions

SA Sakowski, EJ Koubek, KS Chen… - Annals of …, 2024 - Wiley Online Library
Neurodegenerative diseases are increasing in prevalence and place a significant burden on
society. The causes are multifactorial and complex, and increasing evidence suggests a …

The role of neurotransmitter systems in mediating deep brain stimulation effects in Parkinson's disease

F Alosaimi, JT Boonstra, S Tan, Y Temel… - Frontiers in …, 2022 - frontiersin.org
Deep brain stimulation (DBS) is among the most successful paradigms in both translational
and reverse translational neuroscience. DBS has developed into a standard treatment for …