This article reviews the discovery of PCSK9, its structure–function characteristics, and its
presently known and proposed novel biological functions. The major critical function of …

Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …

Hyperlipidemia is a well-established risk factor for developing cardiovascular disease
(CVD). The recent American College of Cardiology and American Heart Association …

Since the discovery of proprotein convertase subtilisin kexin 9 (PCSK9) in 2003, this PC has
attracted a lot of attention from the scientific community and pharmaceutical companies …

Background: Replacing SFAs with vegetable PUFAs has cardiometabolic benefits, but the
effects on liver fat are unknown. Increased dietary n-6 PUFAs have, however, also been …

PCSK9 proprotein convertase subtilisin/kexin type (PCSK9) is a crucial protein in LDL
cholesterol (LDL-C) metabolism by virtue of its pivotal role in the degradation of the LDL …

The hepatic low-density lipoprotein receptor (LDLR) pathway is essential for clearing
circulating LDL cholesterol (LDL-C). Whereas the transcriptional regulation of LDLR is well …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the proteinase K
subfamily of subtilases that reduces the number of LDL receptors (LDLRs) in liver through …

Proprotein convertase subtilisin kexin 9 (Pcsk9) is a subtilisin serine protease with a putative
role in cholesterol metabolism. Pcsk9 expression is down-regulated by dietary cholesterol …

PCSK9 encodes proprotein convertase subtilisin/kexin type 9a (PCSK9), a member of the
proteinase K subfamily of subtilases. Missense mutations in PCSK9 cause an autosomal …