In a neural circuit, synapses transfer information rapidly between neurons and transform this
information during transfer. The diverse computational properties of synapses are shaped by …

Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Amyloid precursor protein (APP) is a key player in Alzheimer's disease (AD). The Aβ
fragments of APP are the major constituent of AD-associated amyloid plaques, and …

The amyloid hypothesis (AH) of Alzheimer's disease (AD) posits that the fundamental cause
of AD is the accumulation of the peptide amyloid beta (Aβ) in the brain. This hypothesis has …

Biochemical and genetic evidence establishes a central role of the amyloid precursor
protein (APP) in Alzheimer disease (AD) pathogenesis. Biochemically, deposition of the β …

Synaptic loss is the major neurobiological substrate of cognitive dysfunction in Alzheimer's
disease (AD). Synaptic failure is an early event in the pathogenesis that is clearly detectable …

Accumulation of amyloid-β (Aβ) peptides in the brain has been suggested to be the primary
event in sequential progression of Alzheimer's disease (AD). Here, we use Drosophila to …

The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD)
pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited …

The Drosophila larval neuromuscular system is relatively simple, containing only 32 motor
neurons in each abdominal hemisegment, and its neuromuscular junctions (NMJs) have …

We tested the hypothesis that amyloid precursor protein (APP) and its relatives function as
vesicular receptor proteins for kinesin-I. Deletion of the Drosophila APP-like gene (Appl) or …